Literature DB >> 582753

Physico-chemical and anlytical studies of penbutolol.

P Hajdú, D Damm.   

Abstract

In the present paper physico-chemical and analytical studies on penbutolol sulfate (Hoe 893d) are reported. In addition to an interpretation of ultraviolet and fluorometric spectra, data are given regarding the dissociation constant, solubility, distribution, and protein binding. The substance and its major metabolte, as well as their glucuronides, are detectable by means of a selective fluormetric method. Moreover, mention is made of the results of a human pharmacokinetic study.

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Year:  1979        PMID： 582753

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  12 in total

1.  Penbutolol: pharmacokinetics, effect on exercise tachycardia, and in vitro inhibition of radioligand binding.

Authors:  D Brockmeier; P Hajdù; W Henke; E Mutschler; D Palm; W Rupp; H Spahn; M T Verho; A Wellstein
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

2.  Is there a relationship between the physical properties and cardioselectivity of beta-adrenoceptor antagonists?

Authors:  D B Jack
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

3.  The effect of single doses of penbutolol and propranolol L.A. on psychomotor performance.

Authors:  A D Broadhurst; A T Monaghan
Journal:  Br J Clin Pharmacol       Date:  1984-05       Impact factor: 4.335

4.  Pharmacokinetics of penbutolol and its metabolites in renal insufficiency.

Authors:  N Bernard; G Cuisinaud; N Pozet; P Y Zech; J Sassard
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

5.  Penbutolol: beta-adrenoceptor interaction and the time course of plasma concentrations explain its prolonged duration of action in man.

Authors:  A Wellstein; D Palm
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

6.  Penbutolol (Hoe 893d) in primary hypertension. Blood pressure effects, tolerance and plasma concentrations.

Authors:  K P Ohman; J Asplund; S Landahl; B Liander
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

7.  Pharmacodynamic and pharmacokinetic study of oral and intravenous penbutolol.

Authors:  J A Vedin; C Wilhelmsson; L Maass; L E Peterson
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

8.  Penbutolol: a preliminary review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris.

Authors:  R C Heel; R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-07       Impact factor: 9.546

9.  Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man.

Authors:  P H Hinderling; O Schmidlin; J K Seydel
Journal:  J Pharmacokinet Biopharm       Date:  1984-06

10.  Penbutolol Pharmacokinetics: the influence of concomitant administration of cimetidine.

Authors:  H Spahn; W Kirch; P Hajdu; E Mutschler; E E Ohnhaus
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953
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