| Literature DB >> 5827349 |
J H Playfair, B W Papermaster, L J Cole.
Abstract
Lethally irradiated mice were injected with small numbers of normal spleen cells and then immunized with sheep erythrocytes. Antibody activity was found in their spleens in localized areas whose number corresponded to the number of spleen cells injected. When sheep and pig erythrocytes were injected together, antibody against each was found in separate areas. Each area may consist of the progeny of a single precursor cell, restricted to forming a single antibody.Entities:
Mesh：
Year: 1965 PMID： 5827349 DOI： 10.1126/science.149.3687.998
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728