Literature DB >> 582693

[Acylaminoalkyl substituted benzoic and phenylalkane acids with hypoglycaemic properties (author's transl)].

K Geisen, M Hübner, V Hitzel, V E Hrstka, W Pfaff, E Bosies, G Regitz, H F Kühnle, F H Schmidt, R Weyer.   

Abstract

Newly developed carbonic acids with hypoglycaemic properties are presented. Their activity is based on an insulin secretion with unusual biphasic dynamics which is seen both after enteral and parenteral administration. In vitro, the substances described have an inhibitory effect on gluconeogenesis in the liver and lipolysis in adipose tissue.

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Year:  1978        PMID: 582693

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN: 0004-4172


  5 in total

1.  How do sulfonylureas approach their receptor in the B-cell plasma membrane?

Authors:  B J Zünkler; G Trube; U Panten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-09       Impact factor: 3.000

2.  Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells.

Authors:  B J Zünkler; S Lenzen; K Männer; U Panten; G Trube
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-02       Impact factor: 3.000

3.  Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide.

Authors:  M G Garrino; W Schmeer; M Nenquin; H P Meissner; J C Henquin
Journal:  Diabetologia       Date:  1985-09       Impact factor: 10.122

4.  Relationships between the Na(+)/K(+) pump and ATP and ADP content in mouse pancreatic islets: effects of meglitinide and glibenclamide.

Authors:  A Elmi; L A Idahl; J Sehlin
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

5.  Effect of a new hypoglycaemic agent (HB 699) on the in vivo secretion of pancreatic hormones in the dog.

Authors:  G Ribes; E R Trimble; J P Blayac; C B Wollheim; R Puech; M M Loubatières-Mariani
Journal:  Diabetologia       Date:  1981-04       Impact factor: 10.122

  5 in total

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