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Literature DB >> 5826524

Protein synthesis by ribosomes from heart muscle: effect of insulin and diabetes.

Abstract

Incorporation of phenylalanine into protein by ribosomes from the heart muscle of rats is decreased when the ribosomes are from alloxan-diabetic animals. Protein synthesis is increased when the ribosomes are obtained from nondiabetic animals I hour after treatment with insulin. The change due to insulin appears to be an alteration in the function of the ribosome.

Entities: Chemical Disease Species

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Year: 1965 PMID： 5826524 DOI： 10.1126/science.149.3688.1102

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

13 in total

1. Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

Authors: Amro Ilaiwy; Miao Liu; Traci L Parry; James R Bain; Christopher B Newgard; Jonathan C Schisler; Michael J Muehlbauer; Florin Despa; Monte S Willis
Journal: Metabolomics Date: 2016-04-23 Impact factor: 4.290

2. Insulin regulation of protein synthesis by muscle ribosomes: effect of the hormone on translation of messenger RNA for a regulatory protein.

Authors: I G Wool; P Cavicchi
Journal: Proc Natl Acad Sci U S A Date: 1966-09 Impact factor: 11.205

6. [Metabolism of the human heart under the effect of insulin. 3. Studies of the myocardial absorption of the nonesterified fatty acids ketone bodies and amino acids].

Authors: W Rudolph; G Hauer
Journal: Klin Wochenschr Date: 1970-02-01

10. Regulation of polyribosome formation and protein synthesis in the uterus. Effect of administration of graded doses of oestradiol-17-beta and actinomycin D on the amino acid-incorporation activity in vitro and the cytoplasmic concentration in vivo of polyribosomes.

Authors: C S Teng; T H Hamilton
Journal: Biochem J Date: 1970-07 Impact factor: 3.857

Protein synthesis by ribosomes from heart muscle: effect of insulin and diabetes.

1. Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

2. Insulin regulation of protein synthesis by muscle ribosomes: effect of the hormone on translation of messenger RNA for a regulatory protein.

3. The relation of RNA and protein synthesis to the sedimentation of muscle ribosomes: effect of diabetes and insulin.

4. The peri-insular acini of the pancreas of the rat.

Review 5. The formation and distribution of ribosomes during hormone-induced growth and development.

6. [Metabolism of the human heart under the effect of insulin. 3. Studies of the myocardial absorption of the nonesterified fatty acids ketone bodies and amino acids].

7. The case for an "abnormal" insulin in diabetes mellitus.

8. Determination of the number of active muscle ribosomes: effect of diabetes and insulin.

9. Formation of active hybrids from subunits of muscle ribosomes from normal and diabetic rats.

10. Regulation of polyribosome formation and protein synthesis in the uterus. Effect of administration of graded doses of oestradiol-17-beta and actinomycin D on the amino acid-incorporation activity in vitro and the cytoplasmic concentration in vivo of polyribosomes.