Literature DB >> 5823315

Berberine: complex with DNA.

A K Krey, F E Hahn.   

Abstract

A complex of calf-thymus DNA with berberine sediments in the analytical ultracentrifuge. The DNA produced systematic changes in the absorption spectrum of berberine which suggest that single alkaloid molecules bind to DNA. Flow dichroism of purines and pyrimidines and of berberine in the complex with DNA had the same signs and magnitudes. Berberine shifted the thermal strand separation profile of DNA to higher temperatures. Therefore, the alkaloid forms a complex with DNA, probably by intercalation.

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Year:  1969        PMID： 5823315     DOI： 10.1126/science.166.3906.755

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  The interaction of plant alkaloids with DNA. II. Berberinium chloride.

Authors:  M W Davidson; I Lopp; S Alexander; W D Wilson
Journal:  Nucleic Acids Res       Date:  1977-08       Impact factor: 16.971

2.  Natural-product inhibitors of human DNA ligase I.

Authors:  G T Tan; S Lee; I S Lee; J Chen; P Leitner; J M Besterman; A D Kinghorn; J M Pezzuto
Journal:  Biochem J       Date:  1996-03-15       Impact factor: 3.857

3.  Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane.

Authors:  D Sun; H S Courtney; E H Beachey
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

4.  Antiproliferative effect of berberine on canine mammary gland cancer cell culture.

Authors:  Reyhaneh Sefidabi; Pejman Mortazavi; Saeed Hosseini
Journal:  Biomed Rep       Date:  2016-11-11

5.  Specificity of deoxyribonucleic Acid intercalating compounds in the control of phenylalanine ammonia lyase and pisatin levels.

Authors:  L A Hadwiger; M E Schwochau
Journal:  Plant Physiol       Date:  1971-03       Impact factor: 8.340

6.  Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo.

Authors:  Yuchen Cai; Qing Xia; Rongzhen Luo; Peiyu Huang; Yueli Sun; Yanxia Shi; Wenqi Jiang
Journal:  J Nat Med       Date:  2013-04-21       Impact factor: 2.343

7.  Inhibition of seed germination by quinolizidine alkaloids : Aspects of allelopathy in Lupinus albus L.

Authors:  M Wink
Journal:  Planta       Date:  1983-08       Impact factor: 4.116

8.  Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves1 and asymmetric leaves2 of Arabidopsis thaliana.

Authors:  Ayami Nakagawa; Hiro Takahashi; Shoko Kojima; Nobuo Sato; Kazuomi Ohga; Byung Yoon Cha; Je-Tae Woo; Kazuo Nagai; Gorou Horiguchi; Hirokazu Tsukaya; Yasunori Machida; Chiyoko Machida
Journal:  Plant Mol Biol       Date:  2012-06-10       Impact factor: 4.076

9.  Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box.

Authors:  Yugang Wang; Michael M Kheir; Yushuang Chai; Jun Hu; Dongming Xing; Fan Lei; Lijun Du
Journal:  PLoS One       Date:  2011-08-22       Impact factor: 3.240

10.  TATA boxes in gene transcription and poly (A) tails in mRNA stability: New perspective on the effects of berberine.

Authors:  Zhi-Yi Yuan; Xi Lu; Fan Lei; Yu-Shuang Chai; Yu-Gang Wang; Jing-Fei Jiang; Tian-Shi Feng; Xin-Pei Wang; Xuan Yu; Xiao-Jin Yan; Dong-Ming Xing; Li-Jun Du
Journal:  Sci Rep       Date:  2015-12-16       Impact factor: 4.379
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