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Literature DB >> 5822140

Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue.

R A Gregory, H J Tracy, K L Agarwal, M I Grossman.

Abstract

Two peptides which are potent stimulants of gastric acid secretion are isolated from Zollinger-Ellison tumour tissue. They have aminoacid constitutions identical with those of human gastrin types I and II as isolated from human antral mucosa, and they are present in similar proportions. Their electrophoretic and chromatographic behaviour corresponds to that of human gastrins. Evidence is presented in respect of the one isolated in greater amount that its aminoacid sequence is probably identical with that of human gastrin type I.

Entities: Disease Gene Species

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Year: 1969 PMID： 5822140 PMCID： PMC1552899 DOI： 10.1136/gut.10.8.603

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

10 in total

1. THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA.

Authors: R A GREGORY; H J TRACY
Journal: Gut Date: 1964-04 Impact factor: 23.059

2. THE ANTRAL HORMONE GASTRIN. STRUCTURE OF GASTRIN.

Authors: H GREGORY; P M HARDY; D S JONES; G W KENNER; R C SHEPPARD
Journal: Nature Date: 1964-12-05 Impact factor: 49.962

3. Gastric secretory responses after portal venous ligation.

Authors: R A GREGORY
Journal: J Physiol Date: 1958-11-10 Impact factor: 5.182

4. A method for biologic assay of gastrin.

Authors: B UVNAS; S EMAS
Journal: Gastroenterology Date: 1961-05 Impact factor: 22.682

5. Energetics of peptide formation.

Authors: J W BREITENBACH; J DERKOSCH; F WESSELY
Journal: Nature Date: 1952-05-31 Impact factor: 49.962

6. Nature of the gastric secretagogue in Zollinger-Ellison tumours.

Authors: R A Gregory; M I Grossman; H J Tracy; P H Bentley
Journal: Lancet Date: 1967-09-09 Impact factor: 79.321

7. Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumors of the Zollinger-Ellison variety.

Authors: J E McGuigan; W L Trudeau
Journal: N Engl J Med Date: 1968-06-13 Impact factor: 91.245

8. Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin.

Authors: J S Morley; H J Tracy; R A Gregory
Journal: Nature Date: 1965-09-25 Impact factor: 49.962

9. Isolation of two gastrins from human antral mucosa.

Authors: R A Gregory; H J Tracy; M I Grossman
Journal: Nature Date: 1966-02-05 Impact factor: 49.962

10. Production of antibodies to synthetic human gastrin I and radioimmunoassay of gastrin in the serum of patients with the zollinger-ellison syndrome.

Authors: J F Stremple; R C Meade
Journal: Surgery Date: 1968-07 Impact factor: 3.982

10 in total

1. Relative abundance of big and little gastrins in the tumours and blood of patients with the Zollinger Ellison syndrome.

Authors: G J Dockray; J H Walsh; E Passaro
Journal: Gut Date: 1975-05 Impact factor: 23.059

Review 2. The Bayliss-Starling lecture 1973. The gastrointestinal hormones: a review of recent advances.

Authors: R A Gregory
Journal: J Physiol Date: 1974-08 Impact factor: 5.182

Review 3. [Physiology and pathophysiology of the antral hormone gastrin (author's transl)].

Authors: T U Hausamen; W P Fritsch
Journal: Klin Wochenschr Date: 1973-10-01

4. Multihormonal, amyloid-producing tumour of the islets of Langerhans in a twelve-year-old boy. Clinical, morphological and biochemical data and review of the literature.

Authors: P Heitz; H Steiner; F Halter; F Egli; J P Kapp
Journal: Virchows Arch A Pathol Pathol Anat Date: 1971