Literature DB >> 5816614

Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.

M S Legator, K A Palmer, S Green, K W Petersen.   

Abstract

Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.

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Year:  1969        PMID： 5816614     DOI： 10.1126/science.165.3898.1139

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Chemical mutagenesis. The Chinese hamster bone marrow as an in vivo test system. I. Cytogenetic results on basic aspects of the methodology, obtained with alkylating agents.

Authors:  W Schmid; D T Arakaki; N A Breslau; J C Culbertson
Journal:  Humangenetik       Date:  1971

2.  Lack of cytogenetic effects in bone marrow and spermatagonial cells in rats treated with polychlorinated biphenyls (Aroclors 1242 and 1254).

Authors:  S Green; J V Carr; K A Palmer; E J Oswald
Journal:  Bull Environ Contam Toxicol       Date:  1975-01       Impact factor: 2.151

Review 3.  The biology of talc.

Authors:  G Y Hildick-Smith
Journal:  Br J Ind Med       Date:  1976-11

4.  Cytological studies in albino rats after oral administration of manganese chloride.

Authors:  T S Dikshith; S V Chandra
Journal:  Bull Environ Contam Toxicol       Date:  1978-06       Impact factor: 2.151

5.  Mutagenicity testing of cyclamate and some pesticides in Drosophila melanogaster.

Authors:  E Vogel; J L Chandler
Journal:  Experientia       Date:  1974-06-15

6.  Endosulfan: lack of cytogenetic effects in male rats.

Authors:  T S Dikshith; K K Datta
Journal:  Bull Environ Contam Toxicol       Date:  1978-12       Impact factor: 2.151

Review 7.  The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism.

Authors:  Peter Spanogiannopoulos; Elizabeth N Bess; Rachel N Carmody; Peter J Turnbaugh
Journal:  Nat Rev Microbiol       Date:  2016-03-14       Impact factor: 60.633

8.  Chromosome aberrations as a measure of mutagenesis: comparisons in vitro and in vivo and in somatic and germ cells.

Authors:  J G Brewen; R J Preston
Journal:  Environ Health Perspect       Date:  1973-12       Impact factor: 9.031

9.  The micronucleus test as an in vivo cytogenetic method.

Authors:  R C Miller
Journal:  Environ Health Perspect       Date:  1973-12       Impact factor: 9.031
  9 in total

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