| Literature DB >> 5815043 |
L Berlowitz, D Pallotta, C H Sibley.
Abstract
The degree of actinomycin D binding to DNA in chromatin is dependent upon the state of repression of chromatin. Living cells bind three times more tritiated actinomycin to euchromatin than to genetically inactive heterochromatin. Extraction of histone results in a general increase in tritiated actinomycin binding and in a ratio of the uptake in heterochromatin to that in euchromatin approaching unity.Entities:
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Year: 1969 PMID： 5815043 DOI： 10.1126/science.164.3887.1527
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728