Literature DB >> 581059

Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung.

M M Husain, W Dehnen.   

Abstract

Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 581059     DOI： 10.1007/bf00364652

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  12 in total

Review 1.  Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

Authors:  F Oesch
Journal:  Xenobiotica       Date:  1973-05       Impact factor: 1.908

Review 2.  Carcinogens, enzyme induction, and gene action.

Authors:  H V Gelboin
Journal:  Adv Cancer Res       Date:  1967       Impact factor: 6.242

3.  Microsomal hydroxylases: induction and role in polycyclic hydrocarbon carcinogenesis and toxicity.

Authors:  H V Gelboin; N Kinoshita; F J Wiebel
Journal:  Fed Proc       Date:  1972 Jul-Aug

4.  Morphological surface changes in the terminal bronchiolar region of NO2-exposed rat lung.

Authors:  D R Parkinson; R J Stephens
Journal:  Environ Res       Date:  1973-03       Impact factor: 6.498

5.  Effect of ozone on benzpyrene hydroxylase activity in the Syrian golden hamster.

Authors:  M S Palmer; D H Swanson; D L Coffin
Journal:  Cancer Res       Date:  1971-06       Impact factor: 12.701

6.  Influence of pollutant gases on benzpyrene hydroxylase activity.

Authors:  M S Palmer; R W Exley; D L Coffin
Journal:  Arch Environ Health       Date:  1972-12

Review 7.  Chemoprophylaxis of carcinogenesis: a review.

Authors:  L W Wattenberg
Journal:  Cancer Res       Date:  1966-07       Impact factor: 12.701

8.  Comparative metabolism of Benzo(a)pyrene in some rodents.

Authors:  M M Husain; W Dehnen; W Monch
Journal:  Toxicol Eur Res       Date:  1978-03

9.  Lipoperoxidation of lung lipids in rats exposed to nitrogen dioxide.

Authors:  H V Thomas; P K Mueller; R L Lyman
Journal:  Science       Date:  1968-02-02       Impact factor: 47.728

10.  Regulation of drug metabolism in man by environmental chemicals and diet.

Authors:  A H Conney; E J Pantuck; K C Hsiao; R Kuntzman; A P Alvares; A Kappas
Journal:  Fed Proc       Date:  1977-04
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.