Literature DB >> 5809744

Possible protective action of antialdosterone compounds in myocardial necrosis in rats.

L R Moudgil.   

Abstract

1. Experimental myocardial necrosis was produced in rats by injection of large doses of isoprenaline.2. The effectiveness of four aldosterone antagonists in preventing this myocardial necrosis was studied.3. The relative effectiveness of these compounds in preventing isoprenaline-induced necrosis was found to be Sc 5233>Sc 9420 (spironolactone)>Sc 11927 and Sc 8109.4. The reported relative effectiveness of these compounds as aldosterone antagonists is Sc 11927>Sc 9420, Sc 8109>Sc 5233.5. The significance of these findings is discussed.

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Year:  1969        PMID： 5809744      PMCID： PMC1703356          DOI： 10.1111/j.1476-5381.1969.tb08296.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Human assay of electrolyte-active steroids and their antagonists.

Authors:  E J ROSS
Journal:  Clin Sci       Date:  1962-10       Impact factor: 6.124

2.  Ectopic arrhythmia provoking action of aldosterone.

Authors:  R B ARORA; P SOMANI
Journal:  Life Sci (1962)       Date:  1962-05

3.  Myocardial infarction and necrotizing arteritis in hamsters, produced by isoproterenol (Isuprel).

Authors:  C P HANDFORTH
Journal:  Med Serv J Can       Date:  1962 Jul-Aug

4.  Isoproterenol-induced myocardial infarction in animals.

Authors:  C P HANDFORTH
Journal:  Arch Pathol       Date:  1962-02

5.  Severe myocardial necrosis produced by isoproterenol in the rat.

Authors:  C I CHAPPEL; G RONA; T BALAZS; R GAUDRY
Journal:  Arch Int Pharmacodyn Ther       Date:  1959-10-01

6.  The influence of adrenal cortical steroids on cardiac necrosis produced by isoproterenol.

Authors:  C I CHAPPEL; G RONA; R GAUDRY
Journal:  Acta Endocrinol (Copenh)       Date:  1959-11

7.  An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat.

Authors:  G RONA; C I CHAPPEL; T BALAZS; R GAUDRY
Journal:  AMA Arch Pathol       Date:  1959-04

8.  Protection by a steroid-spirolactone against certain types of cardiac necroses.

Authors:  H SELYE
Journal:  Proc Soc Exp Biol Med       Date:  1960-06

9.  The adrenergic-cholinergic control of cardiac metabolism and function; physio-pathological and clinical aspects.

Authors:  W RAAB
Journal:  Bibl Cardiol       Date:  1956

10.  Role of aldosterone in myocardial infarction.

Authors:  R B Arora
Journal:  Ann N Y Acad Sci       Date:  1965-01-20       Impact factor: 5.691
  10 in total
  1 in total

1.  Cardiac histological and serum-biochemical changes produced by various adrenergic stimulant drugs in the rat.

Authors:  E Marmo; A P Caputi; R K Saini
Journal:  Basic Res Cardiol       Date:  1973 May-Jun       Impact factor: 17.165
  1 in total

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