Literature DB >> 5809593

Androgen accumulation andbinding to macromolecules in seminal vesicles: inhibition cyproterone.

J M Stern, A J Eisenfeld.   

Abstract

Cyproterone reduces the accumulation of testosterone and dihydrotestosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.

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Year:  1969        PMID： 5809593     DOI： 10.1126/science.166.3902.233

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  The ultrastructure of the accessory sex organs of the male rat. 7. The effect of an anti-androgenic compound, SK and F 22340.

Authors:  K J Tveter; E Dahl
Journal:  Urol Res       Date:  1975

2.  The ultrastructure of the accessory sex organs of the male rat. VI. The effect of cyproterone acetate on the dorsal lobe and the coagulating gland.

Authors:  E Dahl; A Kjaerheim
Journal:  Cell Tissue Res       Date:  1974-03-29       Impact factor: 5.249

3.  [Autoradiographic investigations on epidermal proliferation in male rats after cyproteronacetate administration (author's transl)].

Authors:  H Schell; G H Schmid
Journal:  Arch Dermatol Forsch       Date:  1973

4.  Testosterone regulates the synthesis of major proteins in rat ventral prostate.

Authors:  M G Parker; G T Scrace; W I Mainwaring
Journal:  Biochem J       Date:  1978-01-15       Impact factor: 3.857

5.  The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5-alpha-androstanediols.

Authors:  J A Mahoudeau; C W Bardin; M B Lipsett
Journal:  J Clin Invest       Date:  1971-06       Impact factor: 14.808

6.  Androgen-dependent synthesis of basic secretory proteins by the rat seminal vesicle.

Authors:  S J Higgins; J M Burchell; W I Mainwaring
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857

7.  Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate.

Authors:  E P Giorgi; I M Shirley; J K Grant; J C Stewart
Journal:  Biochem J       Date:  1973-03       Impact factor: 3.857

8.  Testosterone action in the rat ventral prostate. The effects of diethylstilboestrol and cyproterone acetate on the metabolism of ( 3 H)testosterone and the retention of labelled metabolites by rat ventral prostate in vivo and in vitro.

Authors:  J E Belham; G E Neal
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857

9.  Cyproterone acetate-promoted prevention of renal cortical necrosis following testosterone and vasopressin administration.

Authors:  Z Mónus; F A László
Journal:  Br J Exp Pathol       Date:  1979-02
  9 in total

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