Literature DB >> 5807965

Toxin from skin of frogs of the genus Atelopus: differentiation from Dendrobatid toxins.

F A Fuhrman, G J Fuhrman, H S Mosher.   

Abstract

A potent, dialyzable toxin (atelopidtoxin) occurs in the skin of frogs of the genus Atelopus. A concentrate of atelopidtoxin from Atelopus zeteki has an LD(50) in mice of 16 micrograms per kilogram. It differs from batrachotoxin, tetrodotoxin, and saxitoxin, the only known nonprotein substances of greater toxicity, as well as from all toxins previously isolated from amphibia.

Entities:  

Mesh：

Substances：

Year:  1969        PMID： 5807965     DOI： 10.1126/science.165.3900.1376

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Syntheses of Cyclic Guanidine-Containing Natural Products.

Authors:  Yuyong Ma; Saptarshi De; Chuo Chen
Journal:  Tetrahedron       Date:  2015-02-25       Impact factor: 2.457

2.  The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker.

Authors:  Mari Yotsu-Yamashita; Yong H Kim; Samuel C Dudley; Gaurav Choudhary; Arnold Pfahnl; Yasukatsu Oshima; John W Daly
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-22       Impact factor: 11.205

3.  Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.

Authors:  Srinivas R Paladugu; Ryan E Looper
Journal:  Tetrahedron Lett       Date:  2015-11-18       Impact factor: 2.415

Review 4.  A review of chemical defense in harlequin toads (Bufonidae: Atelopus).

Authors:  Kannon C Pearson; Rebecca D Tarvin
Journal:  Toxicon X       Date:  2022-01-22

5.  First identification of 5,11-dideoxytetrodotoxin in marine animals, and characterization of major fragment ions of tetrodotoxin and its analogs by high resolution ESI-MS/MS.

Authors:  Mari Yotsu-Yamashita; Yuka Abe; Yuta Kudo; Raphael Ritson-Williams; Valerie J Paul; Keiichi Konoki; Yuko Cho; Masaatsu Adachi; Takuya Imazu; Toshio Nishikawa; Minoru Isobe
Journal:  Mar Drugs       Date:  2013-08-06       Impact factor: 5.118

Review 6.  Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels.

Authors:  Lorena M Durán-Riveroll; Allan D Cembella
Journal:  Mar Drugs       Date:  2017-10-13       Impact factor: 5.118

Review 7.  Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor.

Authors:  Kanna Adachi; Hayate Ishizuka; Minami Odagi; Kazuo Nagasawa
Journal:  Mar Drugs       Date:  2019-12-26       Impact factor: 5.118
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.