Literature DB >> 580401

[On the metabolism of antipyrine (phenazone) in man (author's transl)].

E Zietz, M Eichelbaum, H J Dengler, G Spiteller.   

Abstract

The metabolism of antipyrine (phenazone) was studied by means of C14-antipyrine labelled at C-3. Besides the metabolites already known two conjugates were isolated and characterized by their mass spectra. The occurrence of 2-hydroxymethyl-3-methyl-1-phenyl-3-pyrazolin-5-one and 3,4-dihydroxy-2,3-dimethyl-1-phenyl-pyrazolidin-5-one could not be confirmed, although 95% of the radioactivity administered was recovered.

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Year:  1978        PMID： 580401

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  10 in total

Review 1.  Assessment of the drug metabolism capacity of the liver.

Authors:  B K Park
Journal:  Br J Clin Pharmacol       Date:  1982-11       Impact factor: 4.335

2.  Studies on the different metabolic pathways of antipyrine in man. I. Oral administration of 250, 500 and 1000 mg to healthy volunteers.

Authors:  M Danhof; D D Breimer
Journal:  Br J Clin Pharmacol       Date:  1979-12       Impact factor: 4.335

3.  Effect of antipyrine coadministration on the kinetics of acetaminophen and lidocaine.

Authors:  G T Blyden; D J Greenblatt; B W LeDuc; J M Scavone
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

4.  Differential effects of enzyme induction on antipyrine metabolite formation.

Authors:  M Danhof; R M Verbeek; C J van Boxtel; J K Boeijinga; D D Breimer
Journal:  Br J Clin Pharmacol       Date:  1982-03       Impact factor: 4.335

5.  Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time.

Authors:  M Danhof; A van Zuilen; J K Boeijinga; D D Breimer
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

6.  Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists.

Authors:  N D Bax; M S Lennard; G T Tucker
Journal:  Br J Clin Pharmacol       Date:  1981-12       Impact factor: 4.335

Review 7.  Noninvasive assessment of microsomal enzyme activity in occupational medicine: present state of knowledge and future perspectives.

Authors:  M Døssing
Journal:  Int Arch Occup Environ Health       Date:  1984       Impact factor: 3.015

8.  Preparative isolation and purification of urinary conjugates in antipyrine metabolism in man and rat.

Authors:  J Böttcher; H Bässmann; R Schüppel; W D Lehmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-12       Impact factor: 3.000

Review 9.  Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone).

Authors:  M Volz; H M Kellner
Journal:  Br J Clin Pharmacol       Date:  1980-10       Impact factor: 4.335

10.  4,4'-Dihydroxyphenazone as an urinary metabolite of phenazone in different species including man.

Authors:  H Bässmann; J Böttcher; R Schüppel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-11       Impact factor: 3.000
  10 in total

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