Literature DB >> 580373

[Critical comments on a case history "a death case involving tilidine" (author's transl)].

J Klapetek.   

Abstract

The author looks critically at the description of a suicide case involving a barbiturate dose that could not be determined exactly and doses of hydroxyzine and tilidine. Drugs with a short and a medium short duration of action obviously had the greatest effect. There was no description of an investigation of the gastric contents. The concentration of barbiturates in the blood alone was sufficient to cause death. The deceased also took hydroxyzine, and then finally 750 mg tilidine in capsule form. Tilidine's action is relatively slow in onset. The author discusses tilidine's possible contribution to the cause of death and comes to a different conclusion from the authors of the case report, especially as regards the key words "Tilidine--Intoxication". The authors of the case report ought to have called it "A Death Case Involving Barbiturates, Hydroxyzine and Tilidine" rather than giving is such a suggestive title as "A Death Case Involving Tildine". This would have been a more accurate representation of the facts and would have assisted the reader to grasp the complex toxicological situation more clearly.

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Year:  1978        PMID: 580373     DOI: 10.1007/bf00353273

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN: 0340-5761            Impact factor:   5.153


  9 in total

1.  [Tilidine (Valoron) and anesthesia (preliminary communication)].

Authors:  R Seybold; B Menninger; S Hahn
Journal:  Med Welt       Date:  1975-11-28

2.  The interaction of tilidine and pethidine in postoperative pain.

Authors:  T Tammisto; I Tigerstedt
Journal:  Acta Anaesthesiol Scand       Date:  1975       Impact factor: 2.105

3.  The respiratory effects of tilidine hydrochloride.

Authors:  D G Moyes; H G Kingston
Journal:  S Afr Med J       Date:  1975-07-26

4.  [Valoron intoxication in attempted suicide].

Authors:  J Klapetek
Journal:  Munch Med Wochenschr       Date:  1973-01-26

5.  [Effect of intravenously administered Tilidine-HC1 on human respiration].

Authors:  L S Geisler; H D Rost
Journal:  Arzneimittelforschung       Date:  1972-02

6.  [Pharmacology of a new potent analgesic].

Authors:  M Herrmann; W Steinbrecher; W Heldt
Journal:  Arzneimittelforschung       Date:  1970-08

7.  Comparative respiratory depression of tillidine and morphine.

Authors:  A Romagnoli; A S Keats
Journal:  Clin Pharmacol Ther       Date:  1975-05       Impact factor: 6.875

8.  Comparison of pethidine and tilidine in man.

Authors:  T Tammisto; S Takki; U Aromaa; L Janhunen
Journal:  Acta Anaesthesiol Scand Suppl       Date:  1974

9.  Respiratory depressant action of tilidine during N2O + O2 anaesthesia.

Authors:  T Tammisto; I Tigerstedt
Journal:  Acta Anaesthesiol Scand       Date:  1976       Impact factor: 2.105

  9 in total

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