Literature DB >> 580370

A rapid gas-chromatographic method for the determination of drugs in clinical toxicology.

R Pentz, A Schütt.   

Abstract

A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors. The detection sensitivity of most drugs is high enough to determine their plasma levels in suicidally or accidentally poisoned patients. As shown for 6 different drugs, the limit of detection, the reproducibility and the accuracy are sufficient even for analysis of therapeutical plasma concentrations.

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Year:  1978        PMID： 580370     DOI： 10.1007/bf00368231

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  5 in total

1.  [On the toxicology of carbromal. I. Estimation of carbromal and its hypnotically active metabolites in rats and humans (author's transl)].

Authors:  H W Vohland; S Hadisoemarto; B Wanke
Journal:  Arch Toxicol       Date:  1976-09-15       Impact factor: 5.153

2.  Technique for rapidly separating drugs from biological samples.

Authors:  V Aggarwal; R Bath; I Sunshine
Journal:  Clin Chem       Date:  1974-02       Impact factor: 8.327

3.  A procedure for the rapid analysis of large numbers of urine samples for drugs.

Authors:  L R Goldbaum; P Santinga; A M Dominguez
Journal:  Clin Toxicol       Date:  1972       Impact factor: 4.467

4.  Determination of barbiturates in blood by GLC.

Authors:  H V Street
Journal:  Clin Chim Acta       Date:  1971-09       Impact factor: 3.786

5.  An ultra rapid method for the extraction of drugs from biological fluids.

Authors:  J Ramsey; D B Campbell
Journal:  J Chromatogr       Date:  1971-12-23
  5 in total
  2 in total

1.  [Hemoperfusion with XAD-4 resin in the treatment of a severe parathion intoxication (author's transl)].

Authors:  R Pentz; J Brunn
Journal:  Arch Toxicol       Date:  1979-09       Impact factor: 5.153

2.  Effect of diethyldithiocarbamate on the metabolic elimination of hexobarbital, phenazone, tolbutamide and four halogenated hydrocarbons.

Authors:  C P Siegers; H Biltz; R Pentz
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1981       Impact factor: 2.441
  2 in total

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