Literature DB >> 58025

Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum.

J F Halsey, D C Benjamin.   

Abstract

Deaggregatedhuman gamma-globulin (DHGG) injected into female mice within 24 hr after delivery of a litter enters the colostrum and is absorbed intact through the intestine by nursing neonates. This absorbed HGG was present in the neonatal circulation at concentrations of 0.3 to 0.6 mg/ml of serum under the experimental conditions used. This absorption of HGG by the nursing neonate resulted in a complete, specific, tolerant state to HGG. This tolerant state was stable upon adoptive cell transfer and could not be abrogated by transfer of normal syngeneic spleen cells.

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Year:  1976        PMID： 58025

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  9 in total

1.  Immunologic and genetic factors influencing reproduction. A review.

Authors:  T J Gill; C F Repetti
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307

2.  Immunological unresponsiveness in mice. II. Cellular basis of immunological unresponsiveness induced in foetal and neonatal mice by transfer of human gamma-globulin by the maternal route.

Authors:  S Shinka; T Komatsu; Y Dohi; T Amano
Journal:  Immunology       Date:  1979-05       Impact factor: 7.397

Review 3.  [The immune system of the mucous membranes in healthy and diseased subjects, particularly in subjects with parasitic diseases].

Authors:  R A Allardyce; J Bienenstock
Journal:  Bull World Health Organ       Date:  1984       Impact factor: 9.408

4.  The mucosal immune system in health and disease, with an emphasis on parasitic infection.

Authors:  R A Allardyce; J Bienenstock
Journal:  Bull World Health Organ       Date:  1984       Impact factor: 9.408

Review 5.  Mucosal immunology.

Authors:  J Bienenstock; A D Befus
Journal:  Immunology       Date:  1980-10       Impact factor: 7.397

6.  Maternal dietary antigens and the immune response in the offspring of the guinea-pig.

Authors:  E Telemo; I Jakobsson; B R Weström; H Folkesson
Journal:  Immunology       Date:  1987-09       Impact factor: 7.397

7.  Immunological unresponsiveness of lambs to infection with Haemonchus contortus. Effect of infection in the ewe on the subsequent responsiveness of lambs.

Authors:  A H Shubber; S Lloyd; E J Soulsby
Journal:  Z Parasitenkd       Date:  1984

8.  Neonatal Immune Tolerance Induction to Allow Long-Term Studies With an Immunogenic Therapeutic Monoclonal Antibody in Mice.

Authors:  Matthieu Piccand; Juliana Bessa; Eginhard Schick; Claudia Senn; Carole Bourquin; Wolfgang F Richter
Journal:  AAPS J       Date:  2015-11-24       Impact factor: 4.009

Review 9.  Mucosal immunity: the immunology of breast milk.

Authors:  H B Slade; S A Schwartz
Journal:  J Allergy Clin Immunol       Date:  1987-09       Impact factor: 10.793
  9 in total

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