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Literature DB >> 5797782

Inhibition by aspirin of release of antiheparin activity from human platelets.

Abstract

Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-(14)C-aspirin was significantly greater than that of carboxyl-(14)C-aspirin.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1969 PMID： 5797782 PMCID： PMC1984151 DOI： 10.1136/bmj.3.5667.394

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

12 in total

1. Impaired platelet-connective-tissue reaction in man after aspirin ingestion.

Authors: H J Weiss; L M Aledort
Journal: Lancet Date: 1967-09-02 Impact factor: 79.321

2. Effects of salicylates on human platelets.

Authors: J R O'Brien
Journal: Lancet Date: 1968-04-13 Impact factor: 79.321

3. In vitro acetylation of plasma proteins, enzymes and DNA by aspirin.

Authors: R N Pinckard; D Hawkins; R S Farr
Journal: Nature Date: 1968-07-06 Impact factor: 49.962

4. Effect of anti-inflammatory agents on platelets.

Authors: J R O'Brien
Journal: Lancet Date: 1968-04-27 Impact factor: 79.321

5. Effect of salicylates on human platelets.

Authors: P Barkhan; A Youssef
Journal: Lancet Date: 1968-08-10 Impact factor: 79.321

6. Hypercoagulability and thrombocytopenia after platelet factor 4infusion into rabbits.

Authors: R Farbiszewski; B Lipiński; S Niewiarowski; A Poplawski
Journal: Experientia Date: 1968-06-15

7. Release of platelet factor 4 by adenosine diphosphate and other platelet-aggregating agents.

Authors: A Youssef; P Barkhan
Journal: Br Med J Date: 1968-03-23

8. Neutralization of antithrombin VI (fibrinogen breakdown products) with platelet antiheparin factor (platelet factor 4).

Authors: S Niewiarowski; R Farbiszewski; A Poplawski
Journal: Thromb Diath Haemorrh Date: 1965-11-15

5. [Clinical and in-vitro studies of the therapeutical range of acetylsalicylic-acid to prevent deep vein thrombosis (author's transl)].

Authors: T H Schöndorf; D Hey; H G Lasch
Journal: Klin Wochenschr Date: 1978-11-15

5 in total

Inhibition by aspirin of release of antiheparin activity from human platelets.

1. Impaired platelet-connective-tissue reaction in man after aspirin ingestion.

2. Effects of salicylates on human platelets.

3. In vitro acetylation of plasma proteins, enzymes and DNA by aspirin.

4. Effect of anti-inflammatory agents on platelets.

5. Effect of salicylates on human platelets.

6. Hypercoagulability and thrombocytopenia after platelet factor 4infusion into rabbits.

7. Release of platelet factor 4 by adenosine diphosphate and other platelet-aggregating agents.

8. Neutralization of antithrombin VI (fibrinogen breakdown products) with platelet antiheparin factor (platelet factor 4).

9. The effect of salicylates on the hemostatic properties of platelets in man.

10. The effect of acetylsalicyclic acid on platelet function.

1. Essential thrombocythaemia and peripheral gangrene.

2. Platelet aggregation by rat liver: need for tissue and plasma factors.

3. Gel-filtered human platelets. Ultrastructure, function, and role of proteins in inhibition of aggregation by aspirin.

4. A comparison of an effect of different anti-inflammatory drugs on human platelets.

5. [Clinical and in-vitro studies of the therapeutical range of acetylsalicylic-acid to prevent deep vein thrombosis (author's transl)].