Literature DB >> 57975

The metabolism of lindance and its metabolites gamma-2,3,4,5,6-pentachlorocyclohexene, pentachlorobenzene, and pentachlorophenol in rats and the pathways of lindance metabolism.

R Engst, R M Macholz, M Kujawa, H J Lewerenz, R Plass.   

Abstract

The metabolism of lindane and its metabolites, gamma-PCCH, PCB, and PCP, has been studied in rats. Urine, faeces, blood and important organs were analyzed for free metabolities and those bound as beta-glucuronides. TeCCOL was identified as a main metabolite by GC/MS and gamma-PCCH has been evaluated toxicologically. A degradation scheme, based on experimental results and comprising only one hypothetical metabolite is proposed and discussed.

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Year:  1976        PMID： 57975     DOI： 10.1080/03601237609372028

Source DB:  PubMed          Journal:  J Environ Sci Health B        ISSN： 0360-1234            Impact factor:   1.990


  3 in total

1.  Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the in vivo and in vitro dechlorination of pentachlorophenol.

Authors:  U G Ahlborg; T Thunberg
Journal:  Arch Toxicol       Date:  1978-02-21       Impact factor: 5.153

2.  Studies on toxic effects of gamma-pentachlorocyclo-hexene (PCCH).

Authors:  R M Macholz; M Kujawa; H J Lewerenz; R Plass; R Engst
Journal:  Bull Environ Contam Toxicol       Date:  1986-01       Impact factor: 2.151

3.  Anaerobic dechlorination and degradation of hexachlorocyclohexane isomers by anaerobic and facultative anaerobic bacteria.

Authors:  G Jagnow; K Haider; P C Ellwardt
Journal:  Arch Microbiol       Date:  1977-12-15       Impact factor: 2.552
  3 in total

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