[Hypophysial and ovarian function following a single postnatal estradiol injection. I. Studies by means of intrasplenic ovarian graft (author's transl)].

We have studied the development of the intrasplenic ovarian graft in rats which had received an injection of 100 microgram estradiol benzoate in the first days of life (estrogenized rats). We formed several groups consisting of autografts, homografts in females and males, normal ovarian graft in estrogenized rats and estrogenized ovarian graft in normal rats. In comparison with the results obtained in control groups (rats without postnatal injection), the frequency of luteinised grafts in all experimental groups is reduced by 50-100%. This phenomenon is due not only to the diminution of the hypophysial function but also to ovarian dysfunction, both processes produced by the postnatal estrogen injection.