Literature DB >> 5794393

Oxygen-hemoglobulin dissociation curves: effect of inherited enzyme defects of the red cell.

M Delivoria-Papadopoulos, F A Oski, A J Gottlieb.   

Abstract

The blood of a patient with a deficiency of hexokinase in the red cells and a decreased concentration of 2, 3-diphosphoglycerate in the red cells showed an increased affinity for oxygen, whereas a patient with a deficiency of pyruvate kinase and an elevated concentration of 2, 3-diphosphoglycerate in the red cells had blood with a decreased affinity for oxygen. Defects in red cell glycolysis may alter the oxygen affinity of blood by virtue of their effect on 2, 3-diphosphoglycerate concentrations in red cells.

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Year:  1969        PMID： 5794393     DOI： 10.1126/science.165.3893.601

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Functional aspects of hemoglobin evolution in the mammals.

Authors:  A F Scott; H F Bunn; A H Brush
Journal:  J Mol Evol       Date:  1976-12-30       Impact factor: 2.395

2.  Effects of 2,3-diphosphoglycerate and other organic phosphate compounds on oxygen affinity and intracellular pH of human erythrocytes.

Authors:  J Duhm
Journal:  Pflugers Arch       Date:  1971       Impact factor: 3.657

3.  Increased peripheral oxygen delivery in thyrotoxicosis: role of red cell 2, 3-diphosphoglycerate.

Authors:  L D Miller; H J Sugarman; W W Miller; M Delivoria-Papadopoulos; J F Diaco; A J Gottlieb; F A Oski
Journal:  Ann Surg       Date:  1970-12       Impact factor: 12.969

4.  The interaction of 2,3-diphosphoglycerate with various human hemoglobins.

Authors:  H F Bunn; R W Briehl
Journal:  J Clin Invest       Date:  1970-06       Impact factor: 14.808

5.  Effect of 2,3-diphosphoglycerate on oxygen affinity of blood in sickle cell anemia.

Authors:  S Charache; S Grisolia; A J Fiedler; A E Hellegers
Journal:  J Clin Invest       Date:  1970-04       Impact factor: 14.808

6.  The effects of deoxygenation of adult and fetal hemoglobin on the synthesis of red cell 2,3-diphosphoglycerate and its in vivo consequences.

Authors:  F A Oski; A J Gottlieb; W W Miller; M Delivoria-Papadopoulos
Journal:  J Clin Invest       Date:  1970-02       Impact factor: 14.808

Review 7.  Erythrocyte pyruvate kinase deficiency: 2015 status report.

Authors:  Rachael F Grace; Alberto Zanella; Ellis J Neufeld; D Holmes Morton; Stefan Eber; Hassan Yaish; Bertil Glader
Journal:  Am J Hematol       Date:  2015-08-14       Impact factor: 10.047
  7 in total

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