Literature DB >> 5793975

Serum elastase inhibitor deficiency and alpha 1-antitrypsin deficiency in patients with obstructive emphysema.

G M Turino, B D Garg, S Keller, M M Levi, I Mandl.   

Abstract

A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with alpha(1)-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

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Year:  1969        PMID： 5793975     DOI： 10.1126/science.165.3894.709

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  15 in total

Review 1.  Antitrypsin and the liver.

Authors:  P W Brunt
Journal:  Gut       Date:  1974-07       Impact factor: 23.059

2.  Alpha antitrypsin deficiency and pulmonary emphysema.

Authors:  M C Jones; G O Thomas
Journal:  Thorax       Date:  1971-11       Impact factor: 9.139

Review 3.  Alpha-1-antitrypsin: physiology, genetics and pathology.

Authors:  F Kueppers
Journal:  Humangenetik       Date:  1971

4.  Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.

Authors:  Ani Manichaikul; Eric A Hoffman; Joanna Smolonska; Wei Gao; Michael H Cho; Heather Baumhauer; Matthew Budoff; John H M Austin; George R Washko; J Jeffrey Carr; Joel D Kaufman; Tess Pottinger; Charles A Powell; Cisca Wijmenga; Pieter Zanen; Harry J M Groen; Dirkje S Postma; Adam Wanner; Farshid N Rouhani; Mark L Brantly; Rhea Powell; Benjamin M Smith; Dan Rabinowitz; Leslie J Raffel; Karen D Hinckley Stukovsky; James D Crapo; Terri H Beaty; John E Hokanson; Edwin K Silverman; Josée Dupuis; George T O'Connor; H Marike Boezen; Stephen S Rich; R Graham Barr
Journal:  Am J Respir Crit Care Med       Date:  2014-02-15       Impact factor: 21.405

5.  The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility.

Authors:  Haiping Wang; Qi Li; Yujun Shen; Aimin Sun; Xiaoguang Zhu; Shengyun Fang; Yuxian Shen
Journal:  Mol Cell Biochem       Date:  2010-10-01       Impact factor: 3.396

6.  Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells.

Authors:  Angelia D Lockett; Daniela N Petrusca; Matthew J Justice; Christophe Poirier; Karina A Serban; Natalia I Rush; Malgorzata Kamocka; Dan Predescu; Sanda Predescu; Irina Petrache
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-06-19       Impact factor: 5.464

7.  alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.

Authors:  Irina Petrache; Iwona Fijalkowska; Terry R Medler; Jarrett Skirball; Pedro Cruz; Lijie Zhen; Horia I Petrache; Terence R Flotte; Rubin M Tuder
Journal:  Am J Pathol       Date:  2006-10       Impact factor: 4.307

8.  Isolation of alpha 1-protease inhibitor from human normal and malignant ovarian tissue.

Authors:  A Bagdasarian; J Wheeler; G J Stewart; S S Ahmed; R W Colman
Journal:  J Clin Invest       Date:  1981-01       Impact factor: 14.808

9.  A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema.

Authors:  Irina Petrache; Iwona Fijalkowska; Lijie Zhen; Terry R Medler; Emile Brown; Pedro Cruz; Kang-Hyeon Choe; Laimute Taraseviciene-Stewart; Robertas Scerbavicius; Lee Shapiro; Bing Zhang; Sihong Song; Dan Hicklin; Norbert F Voelkel; Terence Flotte; Rubin M Tuder
Journal:  Am J Respir Crit Care Med       Date:  2006-03-02       Impact factor: 21.405

10.  Alpha-1 Antitrypsin and Lung Cell Apoptosis.

Authors:  Karina A Serban; Irina Petrache
Journal:  Ann Am Thorac Soc       Date:  2016-04
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