Literature DB >> 579150

[Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)].

H J Dengler, M Eichelbaum.   

Abstract

The influences of polymorphisms and pharmacokinetic defects of drug metabolism as causes of toxic drug reactions are presented. The different mechanisms of toxic side effects mediated by alterations of the metabolism and excretion of drugs are discussed.

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Year:  1977        PMID： 579150

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  14 in total

1.  The influence of enzyme induction on polymorphic sparteine oxidation.

Authors:  M Eichelbaum; S Mineshita; E E Ohnhaus; C Zekorn
Journal:  Br J Clin Pharmacol       Date:  1986-07       Impact factor: 4.335

2.  Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers.

Authors:  T Leemann; P Dayer; U A Meyer
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

3.  Contribution of the genetic status of oxidative metabolism to variability in the plasma concentrations of beta-adrenoceptor blocking agents.

Authors:  P Dayer; L Balant; A Küpfer; F Courvoisier; J Fabre
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

Review 4.  Assessment of the drug metabolism capacity of the liver.

Authors:  B K Park
Journal:  Br J Clin Pharmacol       Date:  1982-11       Impact factor: 4.335

5.  Interactions of bupranolol with the polymorphic debrisoquine/sparteine monooxygenase (CYP2D6).

Authors:  J Pressacco; R Muller; W Kalow
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

Review 6.  Defective oxidation of drugs: pharmacokinetic and therapeutic implications.

Authors:  M Eichelbaum
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

7.  6 beta-hydroxycortisol excretion in relation to polymorphic N-oxidation of sparteine.

Authors:  B K Park; M Eichelbaum; E E Ohnhaus
Journal:  Br J Clin Pharmacol       Date:  1982-05       Impact factor: 4.335

8.  Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation.

Authors:  C Zekorn; G Achtert; H J Hausleiter; C H Moon; M Eichelbaum
Journal:  Klin Wochenschr       Date:  1985-11-15

9.  Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of "edge effect" and cultivating an ethical bridge between omics innovations and society.

Authors:  Vural Ozdemir; Guilherme Suarez-Kurtz; Raphaëlle Stenne; Andrew A Somogyi; Toshiyuki Someya; S Oğuz Kayaalp; Eugene Kolker
Journal:  OMICS       Date:  2009-02

10.  Defective N-oxidation of sparteine in man: a new pharmacogenetic defect.

Authors:  M Eichelbaum; N Spannbrucker; B Steincke; H J Dengler
Journal:  Eur J Clin Pharmacol       Date:  1979-09       Impact factor: 2.953
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