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Literature DB >> 578707

Serum concentrations of clozapine determined by nitrogen selective gas chromatography.

Abstract

A simple gas-liquid-chromatographic method employing a nitrogen selective detector for the quantitative determination of clozapine in serum is presented. The method involves after the addition of dibenzepine as internal standard the extraction into diethylether followed by analysis of the extract dissolved in methanol. Detector linearity was established over the range of 100-1000 ng/ml serum. Clozapine levels of 9 manic patients analysed by this method are presented and discussed. A linear relationship between daily intake (mg/kg body weight) and serum levels (ng/ml) was established.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1977 PMID： 578707 DOI： 10.1007/bf00330823

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

6 in total

1. [Antipsychotic efficacy in relation to plasma levels of clozapine (author's transl)].

Authors: M Ackenheil; H Bräu; A Burkhart; A Franke; W Pacha
Journal: Arzneimittelforschung Date: 1976

2. Clozapine and haloperidol in a single-blind cross-over trial: therapeutic and biochemical aspects in the treatment of schizophrenia.

Authors: J Gerlach; P Koppelhus; E Helweg; A Monrad
Journal: Acta Psychiatr Scand Date: 1974 Impact factor: 6.392

3. [Pharmacological and neurochemical effects of clozapine (Leponex): new aspects in the drug therapy of schizophrenia].

Authors: H R Bürki; W Ruch; H Asper; M Baggiolini; G Stille
Journal: Schweiz Med Wochenschr Date: 1973-12-01

4. [Exchange of aromatically bound halogen for OH- and SCH3-groups in metabolising clozapine in the human organism (author's transl)].

Authors: B Stock; G Spiteller; R Heipertz
Journal: Arzneimittelforschung Date: 1977

5. [Treatment of manic psychosis with clozapine (author's transl)].

Authors: P Müller; R Heipertz
Journal: Fortschr Neurol Psychiatr Grenzgeb Date: 1977-07

6. Clozapine (Leponex) compared with chlorpromazine: a double-blind evaluation of pharmacological and clinical properties.

Authors: B Ekblom; J E Haggstrom
Journal: Curr Ther Res Clin Exp Date: 1974-09

6 in total

8 in total

7. Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.

Authors: L V Rao; M L Snyder; G M Vallaro
Journal: J Clin Lab Anal Date: 2009 Impact factor: 2.352

Review 8. Pharmacokinetics and pharmacodynamics of clozapine.

Authors: M W Jann; S R Grimsley; E C Gray; W H Chang
Journal: Clin Pharmacokinet Date: 1993-02 Impact factor: 6.447

8 in total

Serum concentrations of clozapine determined by nitrogen selective gas chromatography.

1. [Antipsychotic efficacy in relation to plasma levels of clozapine (author's transl)].

2. Clozapine and haloperidol in a single-blind cross-over trial: therapeutic and biochemical aspects in the treatment of schizophrenia.

3. [Pharmacological and neurochemical effects of clozapine (Leponex): new aspects in the drug therapy of schizophrenia].

4. [Exchange of aromatically bound halogen for OH- and SCH3-groups in metabolising clozapine in the human organism (author's transl)].

5. [Treatment of manic psychosis with clozapine (author's transl)].

6. Clozapine (Leponex) compared with chlorpromazine: a double-blind evaluation of pharmacological and clinical properties.

1. Clozapine: an appraisal of its pharmacoeconomic benefits in the treatment of schizophrenia.

2. Multiple-dose pharmacokinetics of clozapine in patients.

Review 3. Antipsychotic drugs. Clinical pharmacokinetics of potential candidates for plasma concentration monitoring.

4. Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age.

Review 5. Clozapine plasma level monitoring: current status.

Review 6. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia.

7. Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.

Review 8. Pharmacokinetics and pharmacodynamics of clozapine.