| Literature DB >> 578424 |
S D Clemans, C Davison, R F Koss, B Dorrbecker, P E O'Melia, R W Ross, J Edelson.
Abstract
A gas chromatograph-mass fragmentography method for simultaneous assay of 17-monochloroacetyl-ajmaline (MCAA) and its hydrolysis product, ajmaline, is described. Recovery of both compounds from whole blood averaged 71%. About 5% of MCAA was hydrolyzed during the assay procedure. The method was accurate and precise to within a few percent. It was suitable for assays of blood levels in the dog after an i.v. dose of 2 mg/kg or an oral dose of 5 mg/kg.Entities:
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Year: 1977 PMID： 578424
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172