Literature DB >> 5783718

Acetylcholine receptor: covalent attachment of depolarizing groups at the active site.

I Silman, A Karlin.   

Abstract

Following reduction of the acetylcholine receptor in the electroplax with dithiothreitol, the quaternary ammonium compounds bromoacetylcholine bromide and the p-nitrophenyl ester of (p-carboxyphenyl) trimethylammonium iodide react near the active site probably with a sulfhydryl group. The covalently attached quaternary ammonium moieties additionally interact with the active site noncovalently to activate the receptor and cause depolarization of the cell.

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Year:  1969        PMID： 5783718     DOI： 10.1126/science.164.3886.1420

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

1.  Rearrangement of nicotinic receptor alpha subunits during formation of the ligand binding sites.

Authors:  M Mitra; C P Wanamaker; W N Green
Journal:  J Neurosci       Date:  2001-05-01       Impact factor: 6.167

2.  Engineering light-regulated ion channels.

Authors:  Doris L Fortin; Timothy W Dunn; Richard H Kramer
Journal:  Cold Spring Harb Protoc       Date:  2011-06-01

3.  Structural and functional studies of the nicotinic acetylcholine receptor by solid-state NMR.

Authors:  P T F Williamson; B H Meier; A Watts
Journal:  Eur Biophys J       Date:  2004-01-22       Impact factor: 1.733

4.  Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica.

Authors:  Scott B Hansen; Todd T Talley; Zoran Radic; Palmer Taylor
Journal:  J Biol Chem       Date:  2004-04-06       Impact factor: 5.157

5.  The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor.

Authors:  P T F Williamson; A Verhoeven; K W Miller; B H Meier; A Watts
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-07       Impact factor: 11.205

6.  The irreversible binding of acetylcholine mustard to muscarinic receptors in intestinal smooth muscle of the guinea-pig.

Authors:  D A Robinson; J G Taylor; J M Young
Journal:  Br J Pharmacol       Date:  1975-03       Impact factor: 8.739

7.  Functional contribution of neuronal AChR subunits revealed by antisense oligonucleotides.

Authors:  M Listerud; A B Brussaard; P Devay; D R Colman; L W Role
Journal:  Science       Date:  1991-12-06       Impact factor: 47.728

8.  Activation of the frog sartorius acetylcholine receptor by a covalently attached group.

Authors:  R N Cox; A Karlin; P W Brandt
Journal:  J Membr Biol       Date:  1979-12-14       Impact factor: 1.843

9.  Characterization and partial purification of the acetylcholine receptor from Torpedo electroplax.

Authors:  M E Eldefrawi; A T Eldefrawi
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

10.  Developmental regulation of multiple nicotinic AChR channel subtypes in embryonic chick habenula neurons: contributions of both the alpha 2 and alpha 4 subunit genes.

Authors:  A B Brussaard; X Yang; J P Doyle; S Huck; L W Role
Journal:  Pflugers Arch       Date:  1994-11       Impact factor: 3.657
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