Literature DB >> 578295

Isoelectric focusing pattern of acid hydrolases in cultured fibroblasts, leucocytes and cell-free amniotic fluid.

H Christomanou, C Cáp, K Sandhoff.   

Abstract

The activities of 9 acid hydrolases were determined in cell-free amniotic fluid, leucocytes and cultured fibroblasts using fluorogenic substrates. The specific activities of beta-glucosidase, alpha-fucosidase, beta-hexosaminidase, and arylsulphatase A and B were found to be in the same range in cell-free amniotic fluid and in leucocyties. The isoenzyme pattern of these 5 hydrolases as well as that of acid phosphatase and alpha-mannosidase showed some similarities in all three specimens studied; the pattern of alpha- and beta-galactosidase obtained by isoelectric focusing was different in the 2 types of cells studied and in the cell-free amniotic fluid.

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Year:  1977        PMID： 578295     DOI： 10.1055/s-0028-1091520

Source DB:  PubMed          Journal:  Neuropadiatrie        ISSN： 0028-3797


  9 in total

1.  Sphingolipid activator protein 1 deficiency in metachromatic leucodystrophy with normal arylsulphatase A activity. A clinical, morphological, biochemical, and immunological study.

Authors:  W Schlote; K Harzer; H Christomanou; B C Paton; B Kustermann-Kuhn; B Schmid; J Seeger; U Beudt; I Schuster; U Langenbeck
Journal:  Eur J Pediatr       Date:  1991-06       Impact factor: 3.183

2.  Prenatal monitoring for Wolman's disease in a pregnancy at risk: first case in the Federal Republic of Germany.

Authors:  H Christomanou; C Cáp
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

3.  Wolman's disease: clinical, biochemical and ultrastructural studies in an unusual case without striking adrenal calcification.

Authors:  J Schaub; G E Janka; H Christomanou; K Sandhoff; W Permanetter; G Hübner; P Meister
Journal:  Eur J Pediatr       Date:  1980-10       Impact factor: 3.183

4.  Absence of alpha-fucosidase activity in two sisters showing a different phenotype.

Authors:  H Christomanou; D Beyer
Journal:  Eur J Pediatr       Date:  1983-03       Impact factor: 3.183

5.  Biochemical, genetic, psychometric, and neuropsychological studies in heterozygotes of a family with globoid cell leucodystrophy (Krabbe's disease).

Authors:  H Christomanou; S Jaffé; J Martinius; C Cáp; K Betke
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

6.  The cytotoxicity of chrysotile asbestos fibers to pulmonary alveolar macrophages. I. Effects of inhibitors of ADP-ribosyl transferase.

Authors:  D Nadeau; D A Lane
Journal:  Cell Biol Toxicol       Date:  1988-03       Impact factor: 6.691

7.  Prenatal diagnosis of Tay-Sachs disease in cell-free amniotic fluid.

Authors:  H Christomanou; C Cáp; K Sandhoff
Journal:  Klin Wochenschr       Date:  1978-11-15

8.  Biochemical, psychometric, and neuropsychological studies in heterozygotes for various lipidoses. Preliminary results.

Authors:  H Christomanou; J Martinius; S Jaffé; K Betke; C Förster
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

9.  Leukocyte beta-glucosidase in homozygotes and heterozygotes for Gaucher disease.

Authors:  S S Raghavan; J Topol; E H Kolodny
Journal:  Am J Hum Genet       Date:  1980-03       Impact factor: 11.025
  9 in total

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