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Literature DB >> 5780400

Hemodialysis properties of clindamycin (7-chloro-7-deoxylincomycin).

Abstract

The effect of hemodialysis (Kolff-type machine) on clindamycin blood levels in anuric patients was studied. At 1 hr after oral ingestion of drug, blood levels ranged from 1.23 to 5.17 mug/ml and fell thereafter. Half-times for peripheral removal were 3.36 mug/ml +/- 0.22 when subjects were "off" dialysis and 3.14 mug/ml +/- 0.09 during dialysis. Their difference was not statistically significant, indicating that hemodialysis does not affect the blood level of clindamycin. In all studies, significant levels of the antibiotic were present at 12 hr.

Entities: Chemical Species

Mesh：

Substances：
Lincomycin

Year: 1969 PMID： 5780400 PMCID： PMC377709 DOI： 10.1128/am.17.3.446-448.1969

Source DB: PubMed Journal: Appl Microbiol ISSN： 0003-6919

8 in total

1. HUMAN PHARMACOLOGICAL STUDIES OF LINCOMYCIN, A NEW ANTIBIOTIC FOR GRAM-POSITIVE ORGAMISMS.

Authors: P MA; M LIM; J H NODINE
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1963

2. CLINICAL EXPERIENCE WITH LINCOMYCIN.

Authors: W J HOLLOWAY; E G SCOTT
Journal: Am J Med Sci Date: 1965-06 Impact factor: 2.378

3. MICROBIOLOGICAL, PHARMACOLOGICAL AND CLINICAL STUDIES OF LINCOMYCIN.

Authors: K KAPLAN; W H CHEW; L WEINSTEIN
Journal: Am J Med Sci Date: 1965-08 Impact factor: 2.378

4. Simple venipuncture for hemodialysis.

Authors: J E CIMINO; M J BRESCIA
Journal: N Engl J Med Date: 1962-09-20 Impact factor: 91.245

5. The referring physician and the artificial kidney.

Authors: L B BERMAN; J C ROSE
Journal: GP Date: 1958-03

6. Dialysis in treatment of uremia: artificial kidney and peritoneal lavage.

Authors: W J KOLFF
Journal: AMA Arch Intern Med Date: 1954-07

7. Comparison of in vitro antibacterial activities of 7-chloro-7-deoxylincomycin, lincomycin, and erythromycin.

Authors: D W Garrison; R M DeHaan; J B Lawson
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1967

8. Chronic hemodialysis using venipuncture and a surgically created arteriovenous fistula.

Authors: M J Brescia; J E Cimino; K Appel; B J Hurwich
Journal: N Engl J Med Date: 1966-11-17 Impact factor: 91.245

8 in total

7 in total

7. Differences in kinetic properties of drugs: implications as to the selection of a particular drug for use in patients with renal failure with special emphasis on antibiotics and beta-adrenoceptor blocking agents.

Authors: J Fabre; H M Fox; P Dayer; L Balant
Journal: Clin Pharmacokinet Date: 1980 Sep-Oct Impact factor: 6.447

7 in total

Hemodialysis properties of clindamycin (7-chloro-7-deoxylincomycin).

1. HUMAN PHARMACOLOGICAL STUDIES OF LINCOMYCIN, A NEW ANTIBIOTIC FOR GRAM-POSITIVE ORGAMISMS.

2. CLINICAL EXPERIENCE WITH LINCOMYCIN.

3. MICROBIOLOGICAL, PHARMACOLOGICAL AND CLINICAL STUDIES OF LINCOMYCIN.

4. Simple venipuncture for hemodialysis.

5. The referring physician and the artificial kidney.

6. Dialysis in treatment of uremia: artificial kidney and peritoneal lavage.

7. Comparison of in vitro antibacterial activities of 7-chloro-7-deoxylincomycin, lincomycin, and erythromycin.

8. Chronic hemodialysis using venipuncture and a surgically created arteriovenous fistula.

1. Drug kinetics and artificial kidneys.

2. A studyof the pharmacokinetics of clidamycin in normal subjects and patients with chronic renal failure.

3. Clindamycin bioavailability from clindamycin-2-palmitate and clindamycin-2-hexadecylcarbonate in man.

4. Clinical uses and control of rifampicin and clindamycin.

Review 5. Clinical pharmacokinetics of antibiotics in patients with impaired renal function.

Review 6. Drug therapy in patients undergoing haemodialysis. Clinical pharmacokinetic considerations.

7. Differences in kinetic properties of drugs: implications as to the selection of a particular drug for use in patients with renal failure with special emphasis on antibiotics and beta-adrenoceptor blocking agents.