| Literature DB >> 577897 |
G Lotti, G Delitala, L Devilla, S Alagna, A Masala.
Abstract
The effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and triiodothyronine uptake by Sephadex G-25 (RT3U%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 day course of treatment with propranolol. These results suggest that propranolol has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretion.Entities:
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Year: 1977 PMID： 577897 DOI： 10.1111/j.1365-2265.1977.tb03322.x
Source DB: PubMed Journal: Clin Endocrinol (Oxf) ISSN： 0300-0664 Impact factor: 3.478