Literature DB >> 5775686

Preparation, properties and metabolism of 5,6-monoepoxy-3-dehydroretinal.

A K Mallia, M R Lakshmanan, K V John, H R Cama.   

Abstract

1. 5,6-Monoepoxy-3-dehydroretinal was synthesized from 3-dehydroretinyl acetate and characterized. 2. When fed to vitamin A-deficient rats, 5,6-monoepoxy-3-dehydroretinal was converted into 5,6-monoepoxy-3-dehydrovitamin A and stored in the liver. 3. It was demonstrated that the rat possesses the necessary enzymes for the reduction and oxidation of 5,6-monoepoxy-3-dehydroretinal to the corresponding alcohol and acid respectively. 4. The biological potency of the epoxy-3-dehydroretinal by the rat-growth assay (determined by USP XIV procedure) was 1.07% of that of vitamin A.

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Year:  1969        PMID： 5775686      PMCID： PMC1187489          DOI： 10.1042/bj1110023

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  SEPARATION OF VITAMINS A1 AND A2 AND ALLIED COMPOUNDS BY THIN-LAYER CHROMATOGRAPHY.

Authors:  K V JOHN; M R LAKSHMANAN; F B JUNGALWALA; H R CAMA
Journal:  J Chromatogr       Date:  1965-04

2.  The estimation of vitamin A aldehyde with thiobabituric acid.

Authors:  S FUTTERMAN; L D SASLAW
Journal:  J Biol Chem       Date:  1961-06       Impact factor: 5.157

3.  Studies in vitamin A. 6. Conversion in vivo of vitamin A aldehyde (retinene(1)) to vitamin A(1).

Authors:  J Glover; T W Goodwin; R A Morton
Journal:  Biochem J       Date:  1948       Impact factor: 3.857

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Oxidation of vitamin A1 aldehyde and vitamin A2 aldehyde to the corresponding acids by aldehyde oxidase from different species.

Authors:  M R Lakshmanan; C S Vaidyanathan; H R Cama
Journal:  Biochem J       Date:  1964-03       Impact factor: 3.857

6.  Studies in vitamin A. XVII. Spectroscopic properties of all-trans-vitamin A and vitamin A acetate; analysis of liver oils.

Authors:  H R CAMA; F D COLLINS; R A MORTON
Journal:  Biochem J       Date:  1951-11       Impact factor: 3.857

7.  The preparation and biological activity of methyl 5,6-epoxy-retinoate.

Authors:  B Morgan; J N Thompson
Journal:  Biochem J       Date:  1966-12       Impact factor: 3.857

8.  Preparation, properties and metabolism of 5,6-monoepoxyretinoic acid.

Authors:  K V John; M R Lakshmanan; H R Cama
Journal:  Biochem J       Date:  1967-05       Impact factor: 3.857

9.  METABOLISM AND BIOLOGICAL POTENCY OF 5,6-MONOEPOXYVITAMIN A ALDEHYDE IN THE RAT.

Authors:  M R LAKSHMANAN; F B JUNGALWALA; H R CAMA
Journal:  Biochem J       Date:  1965-04       Impact factor: 3.857

10.  PREPARATION AND PROPERTIES OF 5,6-MONOEPOXYVITAMIN A ACETATE, 5,6-MONOEPOXYVITAMIN A ALCOHOL, 5,6-MONOEPOXYVITAMIN A ALDEHYDE AND THEIR CORRESPONDING 5,8-MONOEPOXY (FURANOID) COMPOUNDS.

Authors:  F B JUNGALWALA; H R CAMA
Journal:  Biochem J       Date:  1965-04       Impact factor: 3.857
  10 in total

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