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Literature DB >> 57740

Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells.

Abstract

The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA polymerase I-dependent DNA synthesis increases. Bleomycin does not appear to have any effect on purified E. coli DNA polymerases I or II. Our results suggest that bleomycin causes nicking of the bacterial chromosome with subsequent DNA synthesis catalyzed by DNA polymerase I.

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Year: 1976 PMID： 57740 PMCID： PMC429510 DOI： 10.1128/AAC.9.2.239

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

31 in total

1. ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI.

Authors: C C RICHARDSON; C L SCHILDKRAUT; H V APOSHIAN; A KORNBERG
Journal: J Biol Chem Date: 1964-01 Impact factor: 5.157

2. Enzymatic synthesis of deoxyribonucleic acid. IX. The polymerase formed after T2 bacteriophage infection of Escherichia coli: a new enzyme.

Authors: H V APOSHIAN; A KORNBERG
Journal: J Biol Chem Date: 1962-02 Impact factor: 5.157

3. Fragmentation of deoxyribonucleic acid by bleomycin.

Authors: C W Haidle
Journal: Mol Pharmacol Date: 1971-11 Impact factor: 4.436

4. The effect of bleomycin on prophage induction and staphylokinase production.

Authors: S Fujimura; T Makino; T Hayashi
Journal: Jpn J Exp Med Date: 1972-02

5. Action of bleomycin on DNA and RNA.

Authors: W E Müller; Z Yamazaki; H J Breter; R K Zahn
Journal: Eur J Biochem Date: 1972-12-18

6. Bleomycin, an antitumor antibiotic. Clinical experience in 274 patients.

Authors: A Yagoda; B Mukherji; C Young; E Etcubanas; C Lamonte; J R Smith; C T Tan; I H Krakoff
Journal: Ann Intern Med Date: 1972-12 Impact factor: 25.391

7. Bleomycin, a selective inhibitor of DNA-dependent DNA polymerase from oncogenic RNA viruses.

Authors: W E Müller; Z I Yamazaki; R K Zahn
Journal: Biochem Biophys Res Commun Date: 1972-02-25 Impact factor: 3.575

8. Induction of bacteriophage by bleomycin.

Authors: C W Haidle; K K Weiss; M L Mace
Journal: Biochem Biophys Res Commun Date: 1972-09-05 Impact factor: 3.575

9. Release of free bases from deoxyribonucleic acid after reaction with bleomycin.

Authors: C W Haidle; K K Weiss; M T Kuo
Journal: Mol Pharmacol Date: 1972-09 Impact factor: 4.436

10. Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo.

Authors: Y Fujiwara; T Kondo
Journal: Biochem Pharmacol Date: 1973-02-01 Impact factor: 5.858

5 in total

1. Quantitative measurement of single- and double-strand breakage of DNA in Escherichia coli by the antitumor antibiotics bleomycin and talisomycin.

Authors: C K Mirabelli; C H Huang; R G Fenwick; S T Crooke
Journal: Antimicrob Agents Chemother Date: 1985-04 Impact factor: 5.191

5. The nucleotide-permeable Escherichia coli cell, a sensitive DNA repair indicator for carcinogens, mutagens, and antitumor agents binding covalently to DNA.

Authors: H W Thielmann; H Gersbach
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1978-09-28