| Literature DB >> 577331 |
Abstract
Oestradiol-decanoate, dissolved in arachis oil and orally administered to rodents, produces oestrogenic effects. Compared on a molecular basis the ester has 0.1-1.0 times the activity of ethinyl oestradiol, dependent on the species and the parameter studied. The effects of oestradiol-decanoate are less or absent when the oil is omitted. It is likely that absorption of the steroid ester takes place via the intestinal lymphatics in conjunction with the oil.Entities:
Keywords: Animals, Laboratory; Biology; Clinical Research; Contraception; Contraceptive Agents, Estrogen--analysis; Contraceptive Agents, Female--analysis; Contraceptive Agents--analysis; Diseases; Endocrine System; Estradiol--administraction and dosage; Estradiol--analysis; Estradiol--side effects; Estrogens; Ethinyl Estradiol--analysis; Family Planning; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Hormones; Ovulation; Physiology; Reproduction; Research Methodology; Urogenital System; Uterine Effects; Uterus; Vaginal Abnormalities; Vaginal Desquamate Effects; Vaginitis
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Year: 1977 PMID： 577331 DOI： 10.1530/acta.0.0850422
Source DB: PubMed Journal: Acta Endocrinol (Copenh) ISSN： 0001-5598