Literature DB >> 5771580

Action of a pyrimido-pyrimidine compound on platelet behaviour in vitro.

C D Forbes, G P McNicol, A S Douglas.   

Abstract

A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8-dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.

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Year:  1969        PMID： 5771580      PMCID： PMC1983431          DOI： 10.1136/bmj.2.5655.483

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  17 in total

1.  INFLUENCE OF A PYRIMIDOPYRIMIDINE DERIVATIVE ON DEAMINATION OF ADENOSINE BY BLOOD.

Authors:  R D BUNAG; C R DOUGLAS; S IMAI; R M BERNE
Journal:  Circ Res       Date:  1964-07       Impact factor: 17.367

2.  THE AGGREGATION OF BLOOD PLATELETS.

Authors:  G V BORN; M J CROSS
Journal:  J Physiol       Date:  1963-08       Impact factor: 5.182

3.  EFFECT OF ANTICOAGULANT DRUGS ON PLATELET AGGREGATION IN THE CHANDLER'S TUBE.

Authors:  G M CUNNINGHAM; G P MCNICOL; A S DOUGLAS
Journal:  Lancet       Date:  1965-04-03       Impact factor: 79.321

4.  PLATELET CLUMPING IN VITRO.

Authors:  J R MITCHELL; A A SHARP
Journal:  Br J Haematol       Date:  1964-01       Impact factor: 6.998

5.  Platelet clumping in vivo.

Authors:  A J HONOUR; J R MITCHELL
Journal:  Nature       Date:  1963-03-09       Impact factor: 49.962

6.  Changes in the distribution of phosphorus in platelet-rich plasma during clotting.

Authors:  G V BORN
Journal:  Biochem J       Date:  1958-04       Impact factor: 3.857

7.  Effect of normal and atheromatous aortic tissue on platelet aggregation in vitro.

Authors:  C R Prentice; G P McNicol; A S Douglas
Journal:  J Clin Pathol       Date:  1966-07       Impact factor: 3.411

8.  Effect of a pyrimido-pyrimidine compound on platelet behaviour in vitro and in vivo.

Authors:  R S Elkeles; J R Hampton; A J Honour; J R Mitchell; J S Prichard
Journal:  Lancet       Date:  1968-10-05       Impact factor: 79.321

9.  The effect on dipyridamole on platelet aggregation and adhesiveness.

Authors:  G R Gray; P A Wilson; A S Douglas
Journal:  Scott Med J       Date:  1968-12       Impact factor: 0.729

10.  Thrombo-embolism and increased platelet adhesiveness in post-splenectomy thrombocytosis.

Authors:  J Hirsh; J A McBride; J V Dacie
Journal:  Australas Ann Med       Date:  1966-05
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  3 in total

1.  Effect of RA233 on platelet function in vitro.

Authors:  A A Hassanein; A G Turpie; G P McNicol; A S Douglas
Journal:  Br Med J       Date:  1970-04-11

Review 2.  Platelets, thrombosis and drugs.

Authors:  J F Mustard; M A Packham
Journal:  Drugs       Date:  1975       Impact factor: 9.546

3.  Effect in vitro on platelet function of two compounds developed from the pyrimido-pyrimidines.

Authors:  S D Slater; A G Turpie; A S Douglas; G P McNicol
Journal:  J Clin Pathol       Date:  1972-05       Impact factor: 3.411
  3 in total

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