Literature DB >> 576943

Treating acute acetaminophen poisoning with acetylcysteine.

R G Peterson, B H Rumack.   

Abstract

A patient ingested 15.6 gm acetaminophen and sought medical attention after seven hours. At that time, her plasma acetaminophen level was 217 microng/ml. Treatment with acetylcysteine was begun eight hours after the ingestion. The clinical course of this patient was characterized by a mild illness with a minor elevation of liver enzyme values. A number of factors predicted severe hepatotoxicity for this patient had she not received treatment.

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Year:  1977        PMID: 576943

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


  12 in total

1.  Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Authors:  Marc R Mansour; Casie Reed; Amy R Eisenberg; Jen-Chieh Tseng; Jean-Claude Twizere; Sarah Daakour; Akinori Yoda; Scott J Rodig; Noa Tal; Chen Shochat; Alla Berezovskaya; Daniel J DeAngelo; Stephen E Sallan; David M Weinstock; Shai Izraeli; Andrew L Kung; Alex Kentsis; A Thomas Look
Journal:  Br J Haematol       Date:  2014-09-26       Impact factor: 6.998

Review 2.  Paracetamol overdosage. Pharmacological considerations and clinical management.

Authors:  L F Prescott
Journal:  Drugs       Date:  1983-03       Impact factor: 9.546

Review 3.  Mechanisms of acetaminophen-induced liver necrosis.

Authors:  Jack A Hinson; Dean W Roberts; Laura P James
Journal:  Handb Exp Pharmacol       Date:  2010

4.  Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?

Authors:  Z Ben-Zvi; B Weissman-Teitellman; S Katz; A Danon
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

Review 5.  Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.

Authors:  Jephte Y Akakpo; Anup Ramachandran; Steven C Curry; Barry H Rumack; Hartmut Jaeschke
Journal:  Arch Toxicol       Date:  2022-01-03       Impact factor: 5.153

Review 6.  Non-narcotic analgesics. Problems of overdosage.

Authors:  T J Meredith; J A Vale
Journal:  Drugs       Date:  1986       Impact factor: 9.546

7.  [N-Acetylcysteine as an antidote in accidental acrylonitrile poisoning].

Authors:  A Buchter; H Peter; H M Bolt
Journal:  Int Arch Occup Environ Health       Date:  1984       Impact factor: 3.015

8.  Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.

Authors:  B H Lauterburg; G B Corcoran; J R Mitchell
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

Review 9.  Role of Noncoding RNAs in Acetaminophen-Induced Liver Injury.

Authors:  Vivek Chowdhary; Pipasha Biswas; Kalpana Ghoshal
Journal:  Gene Expr       Date:  2021-03-23

10.  Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.

Authors:  Anup Ramachandran; Hartmut Jaeschke
Journal:  J Clin Transl Res       Date:  2017-02-12
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