Literature DB >> 576814

The neuromuscular blocking activity of aminodeoxykanamycin as compared with that of other aminoglycoside antibiotics.

A G Paradelis, C Triantaphyllidis, J M Markomichelakis, G Logaras.   

Abstract

Aminodeoxykanamycin (Kaneudomycin) as well as other members of the aminoglycoside antibiotics, has an action at the neuromuscular junction. Kanendomycin was found to be five times less potent than gentamycin, as far as their neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blockade produced by Kanendomycin is not reversed by neostigmine but only by calcium chloride.

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Year:  1977        PMID： 576814

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  4 in total

1.  Neuromuscular blocking activity of dibekacin, a new semisynthetic aminoglycoside antibiotic.

Authors:  A G Paradelis; J S Tsouras; P Latsoudes; T Demetriou; C Triantaphyllidis
Journal:  Experientia       Date:  1980-07-15

2.  Cimetidine increases the neuromuscular blocking activity of aminoglycoside antibiotics.

Authors:  R Bossa; C Benvenuti; I Galatulas
Journal:  Agents Actions       Date:  1982-07

Review 3.  Neurological manifestations and toxicities of the antituberculosis drugs. A review.

Authors:  M R Holdiness
Journal:  Med Toxicol       Date:  1987 Jan-Feb

4.  Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

Authors:  Igor Nudelman; Annie Rebibo-Sabbah; Marina Cherniavsky; Valery Belakhov; Mariana Hainrichson; Fuquan Chen; Jochen Schacht; Daniel S Pilch; Tamar Ben-Yosef; Timor Baasov
Journal:  J Med Chem       Date:  2009-05-14       Impact factor: 7.446
  4 in total

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