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Literature DB >> 5766946

Fluid phase destruction of C2hu by C1hu. I. Its enhancement and inhibition by homologous and heterologous C4.

Abstract

The fluid phase inactivation of C2(hu) by C1(hu) is markedly enhanced by the presence of C4(hu). The enhancement is afforded by C1 inactivated C4(hu), namely C4i(hu), and requires the simultaneous presence of enzymatically active C1. Heterologous C4 of guinea pig origin protects C2(hu) from the inactivation by C1(hu). Thus, in both the fluid phase and on the cellular intermediate, C4(hu) is essential to the specific action of C1(hu) on C2(hu). It is possible that C4i alters C2 so as to present a more suitable substrate to the C1 enzyme or that C4i acts on the C1 to uncover a specificity for native C2.

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Year: 1969 PMID： 5766946 PMCID： PMC2138629 DOI： 10.1084/jem.129.4.679

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

15 in total

1. STUDIES ON HUMAN C'1-ESTERASE. II. FUNCTION OF PURIFIED C'1-ESTERASE IN THE HUMAN COMPLEMENT SYSTEM.

Authors: A L HAINES; I H LEPOW
Journal: J Immunol Date: 1964-03 Impact factor: 5.422

2. Concerning the mechanism of complement action. V. The early steps in immune hemolysis.

Authors: E L BECKER
Journal: J Immunol Date: 1960-03 Impact factor: 5.422

3. Observations on a pro-esterase associated with partially purified first component of human complement (C'1).

Authors: I H LEPOW; O D RATNOFF; F S ROSEN; L PILLEMER
Journal: Proc Soc Exp Biol Med Date: 1956-05

4. Kinetic studies on immune hemolysis. VI. Resolution of the C'y reaction step into two successive processes involving C'2 and C'3.

Authors: L LEVINE; M M MAYER; H J RAPP
Journal: J Immunol Date: 1954-12 Impact factor: 5.422

5. Studies on the mechanism of inactivation of human complement by plasmin and by antigen-antibody aggregates. I. The requirement for a factor resembling C'1 and the role of Ca++.

Authors: I H LEPOW; L WURZ; O D RATNOFF; L PILLEMER
Journal: J Immunol Date: 1954-09 Impact factor: 5.422

6. Immune hemolysis: a simplified method for the preparation of EAC'4 with guinea pig or with human complement.

Authors: T Borsos; H J Rapp
Journal: J Immunol Date: 1967-08 Impact factor: 5.422

7. Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates.

Authors: R M Stroud; K F Austen; M M Mayer
Journal: Immunochemistry Date: 1965-09

8. Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.

Authors: R A Nelson; J Jensen; I Gigli; N Tamura
Journal: Immunochemistry Date: 1966-03

9. Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.

Authors: H J Müller-Eberhard; M J Polley; M A Calcott
Journal: J Exp Med Date: 1967-02-01 Impact factor: 14.307

10. C'1 ESTERASE EFFECT ON ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF THE FOURTH COMPONENT OF COMPLEMENT.

Authors: H J MUELLER-EBERHARD; I H LEPOW
Journal: J Exp Med Date: 1965-05-01 Impact factor: 14.307

6 in total

1. The unactivated form of the first component of human complement, C1.

Authors: I Gigli; R R Porter; R B Sim
Journal: Biochem J Date: 1976-09-01 Impact factor: 3.857

2. Fluid phase destruction of C2 hu by C1 hu. 3. Changes in activity for synthetic substrates upon cell binding, heat inactivation and interaction with C1INH.

Authors: M Kondo; I Gigli; K F Austen
Journal: Immunology Date: 1972-03 Impact factor: 7.397

3. Structural polymorphism of the fourth component of human complement.

Authors: S I Rosenfeld; S Ruddy; K F Austen
Journal: J Clin Invest Date: 1969-12 Impact factor: 14.808

4. [C1-inactivator from guinea pig serum-mechanism of action. I. Effect of the inactivator on C1 in free solution].

Authors: M Loos; W Opferkuch; H Wagner
Journal: Z Med Mikrobiol Immunol Date: 1971

5. Complement metabolism in man: hypercatabolism of the fourth (C4) and third (C3) components in patients with renal allograft rejection and hereditary, angioedema (HAE).

Authors: C B Carpenter; S Ruddy; I H Shehadeh; H J Müller-Eberhard; J P Merrill; K F Austen
Journal: J Clin Invest Date: 1969-08 Impact factor: 14.808

6. Fluid phase destruction of C2hu by C1hu. II. Unmasking by C4ihu of C1hu specificity for C2hu.

Authors: I Gigli; K F Austen
Journal: J Exp Med Date: 1969-10-01 Impact factor: 14.307

6 in total