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Literature DB >> 5763494

Giant hepatic mitochondria: production in mice fed with cuprizone.

Abstract

Giant mitochondria in hepatocytes that have the average size of nuclei can be consistently produced in the liver of weanling mice by feeding them cuprizone (bis-cyclohexanone oxaldihydrazone). The simplicity of the procedure and the consistency of the results make the feeding of cuprizone a new and useful experimental tool for the study of mitochondrial metabolism.

Entities: Chemical Species

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Year: 1969 PMID： 5763494 DOI： 10.1126/science.163.3862.81

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

29 in total

1. Unusual mitochondria in human skeletal muscle.

Authors: H Klug
Journal: Experientia Date: 1975-10-15

2. Chloramphenicol-induced giant hepatic mitochondria.

Authors: M Albring; K Radsak; W Thoenes
Journal: Naturwissenschaften Date: 1975-01

3. Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons.

Authors: Nobuhiko Ohno; Hao Chiang; Don J Mahad; Grahame J Kidd; LiPing Liu; Richard M Ransohoff; Zu-Hang Sheng; Hitoshi Komuro; Bruce D Trapp
Journal: Proc Natl Acad Sci U S A Date: 2014-06-23 Impact factor: 11.205

4. Time-resolved spectroscopy of mitochondria, cells and tissues under normal and pathological conditions.

Authors: B Beauvoit; B Chance
Journal: Mol Cell Biochem Date: 1998-07 Impact factor: 3.396

5. Abnormal DNA patterns in animal mitochondria: ethidium bromide-induced breakdown of closed circular DNA and conditions leading to oligomer accumulation.

Authors: M M Nass
Journal: Proc Natl Acad Sci U S A Date: 1970-12 Impact factor: 11.205

Giant hepatic mitochondria: production in mice fed with cuprizone.

1. Unusual mitochondria in human skeletal muscle.

2. Chloramphenicol-induced giant hepatic mitochondria.

3. Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons.

4. Time-resolved spectroscopy of mitochondria, cells and tissues under normal and pathological conditions.

5. Abnormal DNA patterns in animal mitochondria: ethidium bromide-induced breakdown of closed circular DNA and conditions leading to oligomer accumulation.

6. Ultrastructural changes of mitochondria in pigmented and halo nevi.

7. Clinico-pathological study on macular mutant mouse.

8. Effect of cuprizone feeding on hepatic superoxide dismutase and cytochrome oxidase activities in mice.

9. A characterization of cuprizone-induced giant mouse liver mitochondria.

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