[Effect of glucocorticoids on the level of transcortin-like cytoplasmic receptors].

Experiments were conducted on intact, adrenalectomized and stress-subjected male Wistar rats; the level of transcortin-like cytosol receptors of the lungs heart, kidneys, and the liver was studied by means of 3H-corticosterone and solid-phase sorption. The level of transcortin-like receptors in the cytosol of various tissues in intact rats had the following declining sequence; the lungs, heart, kidneys, liver. In stress the level of transcortin-like receptors in the tissue cytosol displayed a sharp reducion, although the sequence characteristic of intact animals persisted. In adrenalectomized rats stress induced no significant fall in the content of transcortin-like receptors in the tissue cytosol, whereas intraperitoneal administration of cortisol to adrenalectomized rats decreased the level of these receptors. A hypothesis was put forward on the antistress action of transcortin-like cytoplasm receptors.