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Literature DB >> 574949

A slow-release technique for inducing prolonged paralysis by tetrodotoxin.

Abstract

A technique is described for the slow-release of tetrodotoxin in peripheral nerves using a constriction capillary. The capillary, which was implanted under the epineurium of the sciatic nerve, released tetrodotoxin from a 25 micrometer pore. Nerve block was complete after approximately 20 min and lasted 6--9 days. Replacement of the capillary enabled paralysis of the rat hindlimb to be maintained for periods of 21 days and longer. Studies with radioactively labelled compounds demonstrated that the efflux rate from the capillary was dependent on the size of the pore and the relative molecular mass of the compound.

Entities: Chemical Disease Species

Mesh：

Substances：
Tetrodotoxin

Year: 1979 PMID： 574949 DOI： 10.1007/bf00584476

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

11 in total

1. Chronic block of the cervical trunk increases synaptic efficacy in the superior and stellate ganglia of the guinea-pig.

Authors: R Gallego; E Geijo
Journal: J Physiol Date: 1987-01 Impact factor: 5.182

2. Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles.

Authors: J Covault; J R Sanes
Journal: Proc Natl Acad Sci U S A Date: 1985-07 Impact factor: 11.205

3. Activity-dependent regulation of inwardly rectifying potassium currents in non-myelinating Schwann cells in mice.

Authors: T Konishi
Journal: J Physiol Date: 1994-01-15 Impact factor: 5.182

4. Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle.

Authors: J R Sanes; M Schachner; J Covault
Journal: J Cell Biol Date: 1986-02 Impact factor: 10.539

4 in total

A slow-release technique for inducing prolonged paralysis by tetrodotoxin.

1. A physiological correlate of disuse-induced sprouting at the neuromuscular junction.

2. Neural influence on acetylcholine receptor clusters in embryonic development of skeletal muscles.

3. Effects of motor nerve anesthesia and tenotomy on muscle membrane properties.

4. Effects of inactivity on membrane potentials in rat muscle.

5. Comparison of alpha-bungarotoxin binding to skeletal muscles after inactivity or denervation.

6. Effect of muscle disuse on acetylcholine receptors.

7. The trophic influence of tetrodotoxin-inactive nerves on normal and reinnervated rat skeletal muscles.

8. Further studies on the control of ACh sensitivity by muscle activity in the rat.

9. Two factors responsible for the development of denervation hypersensitivity.

10. Non-equivalence of impulse blockade and denervation in the production of membrane changes in rat skeletal muscle.

1. Chronic block of the cervical trunk increases synaptic efficacy in the superior and stellate ganglia of the guinea-pig.

2. Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles.

3. Activity-dependent regulation of inwardly rectifying potassium currents in non-myelinating Schwann cells in mice.

4. Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle.