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Literature DB >> 5743

Dystonic reactions following neuroleptics: time course and proposed mechanisms.

D L Garver, D M Davis, H Dekirmenjian, S Ericksen, L Gosenfeld, J Haraszti.

Abstract

The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergic-cholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1976 PMID： 5743 DOI： 10.1007/BF00735822

Source DB: PubMed Journal: Psychopharmacologia

4 in total

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Authors: S H Curry; J E Derr; H M Maling
Journal: Proc Soc Exp Biol Med Date: 1970-05

4 in total

13 in total

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Journal: Psychiatry (Edgmont) Date: 2005-03

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Journal: J Neurol Date: 2005-10-10 Impact factor: 4.849

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Journal: Psychopharmacology (Berl) Date: 1990 Impact factor: 4.530

7. Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?

Authors: Morvarid Karimi; Stephen M Moerlein; Tom O Videen; Robert R Luedtke; Michelle Taylor; Robert H Mach; Joel S Perlmutter
Journal: Mov Disord Date: 2010-10-19 Impact factor: 10.338

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Journal: J Neurosci Date: 1997-01-15 Impact factor: 6.167

9. Effect of chronic trifluoperazine administration and subsequent withdrawal on the production and persistence of perioral behaviours in two rat strains.

Authors: P Collins; C L Broekkamp; P Jenner; C D Marsden
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

10. Dystonic reactions and the pharmacokinetics of metoclopramide in children.

Authors: D N Bateman; A W Craft; E Nicholson; A D Pearson
Journal: Br J Clin Pharmacol Date: 1983-05 Impact factor: 4.335