Literature DB >> 574197

Phenobarbital dosage for control of neonatal seizures.

L A Lockman, R Kriel, D Zaske, T Thompson, N Virnig.   

Abstract

The relationship of the initial phenobarbital dose to weight, gestational age, blood level, and seizure control was studied in 39 neonates. The blood proportional to the dosage per kilogram, and was not related to weight or gestational age. Seizures remitted only at blood phenobarbital concentrations above 16.9 micrograms per milliliter. Therapeutic levels can be achieved by the intravenous or intramuscular administration of 16 to 23 mg per kilogram of phenobarbital.

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Year:  1979        PMID: 574197     DOI: 10.1212/wnl.29.11.1445

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  16 in total

Review 1.  Pharmacokinetic considerations in the treatment of childhood epilepsy.

Authors:  Jamie T Gilman; Michael Duchowny; Ana E Campo
Journal:  Paediatr Drugs       Date:  2003       Impact factor: 3.022

Review 2.  Dose estimation for children.

Authors:  Nigel Baber; Deborah Pritchard
Journal:  Br J Clin Pharmacol       Date:  2003-11       Impact factor: 4.335

3.  Single enteral loading dose of phenobarbital for achieving its therapeutic serum levels in neonates.

Authors:  Ali H Turhan; Aytug Atici; Cetin Okuyaz; Sercan Uysal
Journal:  Croat Med J       Date:  2010-06       Impact factor: 1.351

4.  Pharmacokinetic and pharmacodynamic data collection in children and neonates. A quiet frontier.

Authors:  J T Gilman; P Gal
Journal:  Clin Pharmacokinet       Date:  1992-07       Impact factor: 6.447

Review 5.  Therapeutic drug monitoring and patient outcome. A review of the issues.

Authors:  A L Tonkin; F Bochner
Journal:  Clin Pharmacokinet       Date:  1994-09       Impact factor: 6.447

Review 6.  Cost-effectiveness of therapeutic drug monitoring.

Authors:  S Vozeh
Journal:  Clin Pharmacokinet       Date:  1987-09       Impact factor: 6.447

Review 7.  Clinical pharmacokinetics in the 21st century. Does the evidence support definitive outcomes?

Authors:  M H Ensom; G A Davis; C D Cropp; R J Ensom
Journal:  Clin Pharmacokinet       Date:  1998-04       Impact factor: 6.447

Review 8.  Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II).

Authors:  J B Besunder; M D Reed; J L Blumer
Journal:  Clin Pharmacokinet       Date:  1988-05       Impact factor: 6.447

Review 9.  Prevention of post-asphyxial hypoxic-ischemic encephalopathy.

Authors:  S M Donn; R A Naglie
Journal:  Indian J Pediatr       Date:  1986 Sep-Oct       Impact factor: 1.967

Review 10.  Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring.

Authors:  E Yukawa
Journal:  Clin Pharmacokinet       Date:  1996-08       Impact factor: 6.447

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