Literature DB >> 573692

Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal.

J N Crawley, R Laverty, R H Roth.   

Abstract

The production of the norepinephrine metabolite 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) in brain regions innervated by the locus coeruleus was increased during naloxone-precipitated withdrawal from chronic morphine treatment. This MHPG increase was reversed by subcutaneous administration of clonidine. Changes in MHPG levels paralleled the elctrophysiological changes found by Aghajanian (1978) in locus coeruleus firing rate with similar treatments, demonstrating the usefulness of MHPG changes as an index of central noradrenergic function.

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Year:  1979        PMID： 573692     DOI： 10.1016/0014-2999(79)90372-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  24 in total

Review 1.  Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

Authors:  J L Scavone; R C Sterling; E J Van Bockstaele
Journal:  Neuroscience       Date:  2013-04-24       Impact factor: 3.590

2.  Simultaneous measurement of biogenic amines and their metabolites in rat brain regions after acute administration of and abrupt withdrawal from butorphanol or morphine.

Authors:  H Wakabayashi; S Tokuyama; I K Ho
Journal:  Neurochem Res       Date:  1995-10       Impact factor: 3.996

3.  Opiate modulation of striatal dopamine and hippocampal norepinephrine release following morphine withdrawal.

Authors:  K Grasing; D Bills; S Ghosh; S D Schlussman; A H Patel; J J Woodward
Journal:  Neurochem Res       Date:  1997-03       Impact factor: 3.996

4.  Primary sensory neurones and naloxone-precipitated morphine withdrawal.

Authors:  J Donnerer
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

5.  Spontaneous morphine withdrawal from the rat spinal cord.

Authors:  D C Marshall; J J Buccafusco
Journal:  Experientia       Date:  1985-09-15

6.  Presynaptic dopaminergic function in the nucleus accumbens following chronic opiate treatment and precipitated withdrawal.

Authors:  S Ghosh; K Grasing
Journal:  Neurochem Res       Date:  1999-01       Impact factor: 3.996

7.  Clonidine dependence in the guinea-pig isolated ileum.

Authors:  H O Collier; N J Cuthbert; D L Francis
Journal:  Br J Pharmacol       Date:  1981-06       Impact factor: 8.739

8.  Efficacy of clonidine in treatment of alcohol withdrawal state.

Authors:  A J Wilkins; W J Jenkins; J A Steiner
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

9.  Effects of naloxone-precipitated withdrawal after a single dose of morphine on catecholamine concentrations in guinea-pig brain.

Authors:  P J Brent; L A Chahl
Journal:  Neurochem Res       Date:  1991-05       Impact factor: 3.996

10.  Acceleration of cerebral noradrenaline turnover after morphine withdrawal and its retardation by acute morphine administration in rats.

Authors:  L M Attila; L Ahtee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000
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