Literature DB >> 573643

Animal model of depression.

R D Porsolt.   

Abstract

A behavioural procedure is described which may provide an animal model for some aspects of human depression. Rats or mice when forced to swim in a restricted space will rapidly cease attempts to escape and become immobile. Immobility is reduced by many clinically effective antidepressant treatments suggesting that the immobile behaviour may reflect a state of lowered mood in the animal. If so the method could be useful as a simple experimental tool for research into the biology and therapeutics of depression.

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Year:  1979        PMID： 573643

Source DB:  PubMed          Journal:  Biomedicine        ISSN： 0300-0893


  51 in total

1.  Acute Post-Traumatic Sleep May Define Vulnerability to a Second Traumatic Brain Injury in Mice.

Authors:  Rachel K Rowe; Jordan L Harrison; Helena W Morrison; Vignesh Subbian; Sean M Murphy; Jonathan Lifshitz
Journal:  J Neurotrauma       Date:  2018-12-18       Impact factor: 5.269

2.  Facts, interpretations, and explanations: a review of Evelyn Fox Keller's Making sense of life.

Authors:  Craig H Kennedy
Journal:  J Appl Behav Anal       Date:  2004

3.  The 2-methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats.

Authors:  Aashish S Morani; Amy Ewald; Katherine M Prevatt-Smith; Thomas E Prisinzano; Bronwyn M Kivell
Journal:  Eur J Pharmacol       Date:  2013-11-04       Impact factor: 4.432

4.  Depressive behavior in the forced swim test can be induced by TRPV1 receptor activity and is dependent on NMDA receptors.

Authors:  Ramy E Abdelhamid; Katalin J Kovács; Myra G Nunez; Alice A Larson
Journal:  Pharmacol Res       Date:  2013-11-04       Impact factor: 7.658

5.  GLP-1 receptor agonist liraglutide reverses long-term atypical antipsychotic treatment associated behavioral depression and metabolic abnormalities in rats.

Authors:  Ajaykumar N Sharma; Sagar S Ligade; Jay N Sharma; Praveen Shukla; Khalid M Elased; James B Lucot
Journal:  Metab Brain Dis       Date:  2014-07-15       Impact factor: 3.584

6.  Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors.

Authors:  Ramy E Abdelhamid; Katalin J Kovacs; Jeffrey D Pasley; Myra G Nunez; Alice A Larson
Journal:  Neuropharmacology       Date:  2013-04-25       Impact factor: 5.250

7.  Experimental Neonatal Sepsis Causes Long-Term Cognitive Impairment.

Authors:  Clarissa M Comim; Regina M Bussmann; Silvia R Simão; Letícia Ventura; Viviane Freiberger; Janini J Patrício; Daphne Palmas; Bruna P Mendonça; Omar J Cassol; João Quevedo
Journal:  Mol Neurobiol       Date:  2015-10-28       Impact factor: 5.590

8.  Diets rich in saturated fat and fructose induce anxiety and depression-like behaviours in the rat: is there a role for lipid peroxidation?

Authors:  Silvia Gancheva; Bistra Galunska; Maria Zhelyazkova-Savova
Journal:  Int J Exp Pathol       Date:  2017-12-06       Impact factor: 1.925

9.  Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice.

Authors:  Alexa H Veenema; Thomas I F H Cremers; Minke E Jongsma; Peter J Steenbergen; Sietse F de Boer; Jaap M Koolhaas
Journal:  Psychopharmacology (Berl)       Date:  2004-09-21       Impact factor: 4.530

10.  Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions.

Authors:  Maria T G Perona; Shonna Waters; Frank Scott Hall; Ichiro Sora; Klaus-Peter Lesch; Dennis L Murphy; Marc Caron; George R Uhl
Journal:  Behav Pharmacol       Date:  2008-09       Impact factor: 2.293
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