Literature DB >> 572522

Regional displacement by sulpiride of [3H]spiperone binding in vivo. Biochemical and behavioural evidence for a preferential action of limbic and nigral dopamine receptors.

C Köhler, S O Ogren, L Haglund, T Angeby.   

Abstract

The regional displacement by sulpiride of [3H]spiperone binding in vivo was studied in the rat. A low dose of sulpiride (20 mg/kg) displaced [3H]spiperone binding in certain limbic regions (olfactory tubercle, septum) and the substantia nigra but not in the nucleus accumbens or striatum. At this does sulpiride preferentially blocked apomorphine induced apomorphine Higher doses of sulpiride (150 and 250 mg/kg), which blocked apomorphine induced stereotypes and induced catalepsy were found to displace [3H]spiperone binding in all regions studied including the striatum and the nucleus accumbens. Haloperidol (0.1 and 1.0 mg/kg) displaced [3H]spiperone to approximately the same extent in all regions studied.

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Year:  1979        PMID： 572522     DOI： 10.1016/0304-3940(79)90074-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  14 in total

1.  Regional distribution and in vivo binding of the atypical antipsychotic drug remoxipride. A biochemical and autoradiographic analysis in the rat brain.

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Review 2.  A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride.

Authors:  Jennifer L Martelle; Michael A Nader
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Review 3.  Mechanisms of action of atypical antipsychotic drugs: a critical analysis.

Authors:  B J Kinon; J A Lieberman
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4.  Atypical neuroleptics increase self-administration of cocaine: an evaluation of a behavioural screen for antipsychotic activity.

Authors:  D C Roberts; G Vickers
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

5.  Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.

Authors:  C Köhler; L Haglund; S O Ogren; T Angeby
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575

6.  Dopaminergic binding sites in rat striatal slices and the action of guanyl nucleotides.

Authors:  M P Martres; P Sokoloff; J C Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-02       Impact factor: 3.000

7.  Selection of dopamine antagonists discriminating various behavioral responses and radioligand binding sites.

Authors:  M P Martres; P Sokoloff; M Delandre; J C Schwartz; P Protais; J Costentin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-02       Impact factor: 3.000

8.  Pharmacological characterization of binding sites identified in rat brain following in vivo administration of [3H]-spiperone.

Authors:  J Chivers; P Jenner; C D Marsden
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

9.  Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats.

Authors:  R E See; A W Toga; G Ellison
Journal:  J Neural Transm Gen Sect       Date:  1990

10.  Effects of dopamine D-1 and D-2 antagonists on decision making by rats: no reversal of neuroleptic-induced attenuation by scopolamine.

Authors:  T Ljungberg; M Enquist
Journal:  J Neural Transm Gen Sect       Date:  1990
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