Literature DB >> 572126

Influence of ethanol and dexamethasone on blood-brain barrier dysfunction to albumin.

L E Rosengren, L I Persson.   

Abstract

Stab-wounded ethanol-intoxicated and non-intoxicated rats were studied with respect to the effect of postoperative dexamethasone treatment on blood-brain barrier dysfunction to bovine albumin. In ethanol-intoxicated rats, fluorescence microscopy revealed an increased area of extravasation of fluorescent tracer, compared to non-intoxicated ones. No significant effect of dexamethasone treatment was observed in non-intoxicated rats. In ethanol-intoxicated rats, dexamethasone treatment resulted in a decreased area of extravasation. Quantitative immuno-electrophoretic measurements of exogeneous bovine albumin confirmed a significant decrease of blood-brain barrier dysfunction to albumin after dexamethasone treatment in ethanol-intoxicated rats, while no significant effect was observed in non-intoxicated ones.

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Year:  1979        PMID： 572126     DOI： 10.1111/j.1600-0404.1979.tb02918.x

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN： 0001-6314            Impact factor:   3.209


  6 in total

Review 1.  Clinical pharmacokinetics of cerebrospinal fluid.

Authors:  M Bonati; J Kanto; G Tognoni
Journal:  Clin Pharmacokinet       Date:  1982 Jul-Aug       Impact factor: 6.447

2.  The effect of acute ethanol intoxication and chronic ethanol consumption on vascular permeability around cerebral stab wounds in mice.

Authors:  E A Heinicke
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

Review 3.  Combined and sequential effects of alcohol and methamphetamine in animal models.

Authors:  Alexandra M Stafford; Bryan K Yamamoto; Tamara J Phillips
Journal:  Neurosci Biobehav Rev       Date:  2021-09-17       Impact factor: 8.989

Review 4.  Alcohol, inflammation, and blood-brain barrier function in health and disease across development.

Authors:  A S Vore; T Deak
Journal:  Int Rev Neurobiol       Date:  2021-08-11       Impact factor: 4.280

5.  Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse.

Authors:  James Haorah; Kathy Schall; Servio H Ramirez; Yuri Persidsky
Journal:  Glia       Date:  2008-01-01       Impact factor: 7.452

6.  Exposure of the cat brain surface to neurosurgical irrigation fluids, hydrogen peroxide and air. Quantitative assay of blood-brain barrier dysfunction.

Authors:  B Vällfors; L E Rosengren; L I Persson
Journal:  Acta Neurochir (Wien)       Date:  1982       Impact factor: 2.216
  6 in total

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