Literature DB >> 57206

Alpha-fetoprotein synthesis by murine lymphoid cells in allogeneic reactions.

R H Keller, T B Tomasi.   

Abstract

Surface-bound alpha-fetoprotein (AFP) was demonstrated by immunofluorescence on approximately 1/3 of splenic lymphocytes in chronic murine graft vs. host (GVH) reactions. Splenic lymphocytes were also shown to have a suppressed phytohemagglutinin (PHA) response compared to controls while lymph node cells from the same GVH animals revealed no surface AFP and had normal PHA responses. Splenic lymphocytes showed marked synthesis of AFP in the GVH and mixed lymphocyte culture (MLC) reactions by [14C]leucine incorporation and by radioimmunoassay in MLC supernates. Lymph node cells, however, demonstrated less synthetic activity and 14C counts in their membrane fractions were not markedly elevated.

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Year:  1976        PMID： 57206      PMCID： PMC2190199          DOI： 10.1084/jem.143.5.1140

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  26 in total

1.  The control of protein synthesis during the stimulation of lymphocytes by phytohaemagglutinin. III. Poly(U) translation and the rate of polypeptide chain elongation.

Authors:  J E Kay; T Ahern; V J Lindsay; J Sampson
Journal:  Biochim Biophys Acta       Date:  1975-01-20

2.  The phagocytosis of Pasteurella tularensis by rat mononuclear cells as influenced by normal serums and various irritants.

Authors:  H MCELREE; C M DOWNS
Journal:  J Infect Dis       Date:  1961 Jul-Aug       Impact factor: 5.226

3.  Immunity to methylcholanthrene-induced sarcomas.

Authors:  R T PREHN; J M MAIN
Journal:  J Natl Cancer Inst       Date:  1957-06       Impact factor: 13.506

4.  Cellular immunity in the mouse. IV. Altered thymic-dependent lymphocyte reactivity in the chronic graft vs host reaction and leukemia virus activation.

Authors:  S M Phillips; H Gleichmann; M S Hirsch; P Black; J P Merrill; R S Schwartz; C B Carpenter
Journal:  Cell Immunol       Date:  1975-01       Impact factor: 4.868

5.  Foetal "antigens" in cancer.

Authors:  P Alexander
Journal:  Nature       Date:  1972-01-21       Impact factor: 49.962

6.  Measurement of IgE in normal and allergic serum by radioimmunoassay.

Authors:  G J Gleich; A K Averbeck; H A Swedlund
Journal:  J Lab Clin Med       Date:  1971-04

Review 7.  Allograft response in vitro.

Authors:  P Häyry; L C Andersson; S Nordling; M Virolainen
Journal:  Transplant Rev       Date:  1972

8.  Supressor cells in the graft vs host reaction.

Authors:  J A Hardin; T M Chused; A D Steinberg
Journal:  J Immunol       Date:  1973-08       Impact factor: 5.422

9.  Immunologic activation of murine leukemia viruses.

Authors:  C J Melief; S Datta; S Louie; R S Schwartz
Journal:  Cancer       Date:  1974-10       Impact factor: 6.860

10.  Enhancement of tumor growth by graft-versus-host reaction.

Authors:  S Okubo; H F Oettgen; S S Caiazza; Z Ovary
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205
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  3 in total

1.  Immunologic and genetic factors influencing reproduction. A review.

Authors:  T J Gill; C F Repetti
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307

Review 2.  Autoantibodies and serum inhibition factors (sif) in patients with myocarditis.

Authors:  B Maisch; P A Berg; K Kochsiek
Journal:  Klin Wochenschr       Date:  1980-03-03

3.  Transferrin support of stimulated lymphocytes.

Authors:  W L Anderson; C G Chase; T B Tomasi
Journal:  In Vitro       Date:  1982-09
  3 in total

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