Literature DB >> 571856

Reversal reaction: the prevention of permanent nerve damage. Comparison of short and long-term steroid treatment.

B Naafs, J M Pearson, H W Wheate.   

Abstract

Borderline leprosy patients with a reversal reaction were studied and short-term steroid treatment compared with prolonged steroid treatment using voluntary muscle testing (VMT) to assess the results. Prolonged steroid treatment was shown to be superior to short-term treatment and free of harmful effects. It is concluded that with the described antireaction treatment, permanent nerve damage can be prevented, provided that the reversal reaction is detected in time (within 3-4 months).

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Year:  1979        PMID: 571856

Source DB:  PubMed          Journal:  Int J Lepr Other Mycobact Dis        ISSN: 0148-916X


  5 in total

1.  High levels of inflammatory cytokines are associated with poor clinical response to steroid treatment and recurrent episodes of type 1 reactions in leprosy.

Authors:  R Manandhar; N Shrestha; C R Butlin; P W Roche
Journal:  Clin Exp Immunol       Date:  2002-05       Impact factor: 4.330

2.  Electro-physiological evaluation of nerves during reactions in leprosy.

Authors:  A K Thacker; S Chandra; R D Mukhija; N B Sarkari
Journal:  J Neurol       Date:  1996-07       Impact factor: 4.849

3.  Nerve damage following intraneural injection of Mycobacterium leprae into rabbits pre-sensitized to mycobacteria.

Authors:  R N Mshana; D P Humber; M Harboe; A Belehu
Journal:  Clin Exp Immunol       Date:  1983-05       Impact factor: 4.330

Review 4.  Understanding the type 1 reactional state for early diagnosis and treatment: a way to avoid disability in leprosy.

Authors:  José Augusto da Costa Nery; Fred Bernardes Filho; Juliana Quintanilha; Alice Miranda Machado; Soraya de Souza Chantre Oliveira; Anna Maria Sales
Journal:  An Bras Dermatol       Date:  2013 Sep-Oct       Impact factor: 1.896

5.  Leprosy Reaction in Thai Population: A 20-Year Retrospective Study.

Authors:  Poonkiat Suchonwanit; Siripich Triamchaisri; Sanchawan Wittayakornrerk; Ploysyne Rattanakaemakorn
Journal:  Dermatol Res Pract       Date:  2015-10-05
  5 in total

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