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Literature DB >> 571350

Effects of cycloheximide on protein synthesis in human lung tumors, regenerating rat liver and hepatomas.

Abstract

10(-4) M cycloheximide (CHM) inhibits leucine incorporation to about the same degree in slices of human lung tumors, rat hepatomas, regenerating livers and normal tissues. At 10(-6) M, CHM has a more pronounced effect on tumor tissue and regenerating liver than on normal tissues. 10(-8) M CHM stimulates protein synthesis in normal rat liver slices.

Entities: Chemical Disease Species

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Year: 1979 PMID： 571350 DOI： 10.1007/bf01922743

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

12 in total

1. Effect of sodium octanoate on leucine incorporation into protein of rat liver slices and of Yoshida ascites hepatoma cells.

Authors: C Agostini
Journal: Experientia Date: 1978-02-15

2. Biphasic effects of translational inhibitors on liver tyrosine aminotransferase.

Authors: F M Baccino; G Cecchini; F Palmucci; V Sverko; L Tessitore; M F Zuretti
Journal: Biochim Biophys Acta Date: 1977-11-02

3. Initiation and elongation of protein synthesis in growing cells: differential inhibition by cycloheximide and emetine.

Authors: N L Oleinick
Journal: Arch Biochem Biophys Date: 1977-07 Impact factor: 4.013

4. Regulation of mammalian protein synthesis in vivo. Protein synthesis in rat liver and kidney after the administration of sublethal doses of cyclohyximide.

Authors: L I Rothblum; T M Devlin; J J Ch'ih
Journal: Biochem J Date: 1976-04-15 Impact factor: 3.857

10. Regulation of mammalian protein synthesis in vivo. Stimulated liver ribonucleic acid synthesis in vivo after cycloheximide treatment.

Authors: J J Ch'ih; L M Pike; T M Devlin
Journal: Biochem J Date: 1977-10-15 Impact factor: 3.857

1 in total

1. Changes in serum proteins and in major liver constituents following carbon tetrachloride and a high-fat choline-free diet in rats.

Authors: C Agostini; M Alfisi
Journal: Experientia Date: 1979-09-15

1 in total

Effects of cycloheximide on protein synthesis in human lung tumors, regenerating rat liver and hepatomas.

1. Effect of sodium octanoate on leucine incorporation into protein of rat liver slices and of Yoshida ascites hepatoma cells.

2. Biphasic effects of translational inhibitors on liver tyrosine aminotransferase.

3. Initiation and elongation of protein synthesis in growing cells: differential inhibition by cycloheximide and emetine.

4. Regulation of mammalian protein synthesis in vivo. Protein synthesis in rat liver and kidney after the administration of sublethal doses of cyclohyximide.

5. Inhibitors of protein synthesis in eukaryotes: tools in cell research.

6. Studies of initiation factors in protein synthesis of host liver and transplantable hepatoma.

7. Regulation of amino acid transport in chick embryo heart cells. II. Adaptive control sites for the "A mediation".

8. A comparative study of in vivo RNA and protein synthesis in rat liver and lung.

9. Regulation of protein synthesis in human diploid fibroblasts: reduced initiation efficiency in resting cultures.

10. Regulation of mammalian protein synthesis in vivo. Stimulated liver ribonucleic acid synthesis in vivo after cycloheximide treatment.

1. Changes in serum proteins and in major liver constituents following carbon tetrachloride and a high-fat choline-free diet in rats.