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Literature DB >> 5710

Preparation and properties of poly 2'-O-ethylcytidylic acid.

Abstract

Poly 2'0-ethylcytidylic acid (poly (Ce)) was prepared by polymerization of 2'-0-ethylcytidine-5'-pyrophosphate with Escherichia coli polynucleotide phosphorylase in the presence of Mn++, and its properties compared with those of poly (rC), poly (Cm) and poly (dC). The neutral form of pOLY (Ce) exhibits properties similar to those of poly (rC) and poly (Cm). It also forms an acid twin-stranded helix with a transition pH of 5.9 in 0.1 M NaCl. The neutral form readily forms a double-stranded helical complex with poly (rI). Relative to poly (Cm), replacement of the 2'-0-methyl by 2-0-ethyl leads to increased enhancement of the thermal stabilities of both the acid helical form of poly (Ce) and its complex with poly (rI).

Entities: Chemical Species

Mesh：

Substances：

Year: 1976 PMID： 5710 PMCID： PMC342942 DOI： 10.1093/nar/3.3.817

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

24 in total

1. N6, O2'-dimethyladenosine a novel methylated ribonucleoside next to the 5' terminal of animal cell and virus mRNAs.

Authors: C Wei; A Gershowitz; B Moss
Journal: Nature Date: 1975-09-18 Impact factor: 49.962

2. Properties of helical polycytidylic acid.

Authors: E O AKINRIMISI; C SANDER; P O TS'O
Journal: Biochemistry Date: 1963 Mar-Apr Impact factor: 3.162

3. THE TAUTOMERIC FORM OF HELICAL POLYRIBOCYTIDYLIC ACID.

Authors: K A HARTMAN; A RICH
Journal: J Am Chem Soc Date: 1965-05-05 Impact factor: 15.419

4. Spectrophotometric studies of nucleic acid derivatives and related compounds as a function of pH. II. Natural and synthetic pyrimidine nucleosides.

Authors: J J FOX; D SHUGAR
Journal: Biochim Biophys Acta Date: 1952-10

5. Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-.

Authors: Y Furuichi; M Morgan; S Muthukrishnan; A J Shatkin
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

6. The preparation of 2'-O-methylcytidine-5'-mono and pyrophosphate, and poly-2'-O-methylcytidylic acid.

Authors: C Janion; B Zmudzka; D Shugar
Journal: Acta Biochim Pol Date: 1970 Impact factor: 2.149

7. Poly(2'-O-methylcytidylate)-oligodeoxyguanylate as a template for the ribonucleic acid directed deoxyribonucleic acid polymerase in ribonucleic acid tumor virus particles and a specific probe for the ribonucleic acid directed enzyme in transformed murine cells.

Authors: G F Gerard; F Rottman; M Green
Journal: Biochemistry Date: 1974-04-09 Impact factor: 3.162

Preparation and properties of poly 2'-O-ethylcytidylic acid.

1. N6, O2'-dimethyladenosine a novel methylated ribonucleoside next to the 5' terminal of animal cell and virus mRNAs.

2. Properties of helical polycytidylic acid.

3. THE TAUTOMERIC FORM OF HELICAL POLYRIBOCYTIDYLIC ACID.

4. Spectrophotometric studies of nucleic acid derivatives and related compounds as a function of pH. II. Natural and synthetic pyrimidine nucleosides.

5. Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-.

6. The preparation of 2'-O-methylcytidine-5'-mono and pyrophosphate, and poly-2'-O-methylcytidylic acid.

7. Poly(2'-O-methylcytidylate)-oligodeoxyguanylate as a template for the ribonucleic acid directed deoxyribonucleic acid polymerase in ribonucleic acid tumor virus particles and a specific probe for the ribonucleic acid directed enzyme in transformed murine cells.

8. Effects of polyadenylic acids on functions of murine RNA tumor viruses.

9. Poly-5-methyldeoxycyctidylic acid and some alkylamino analogs.

10. Polydeoxyribouridylic acid and its complexes with polyribo- and deoxyriboadenylic acids.

1. Oligo(dG)12-18 aggregates result in non-homogeneity of oligo(dG)12-18.poly(C) type primer-template.