Literature DB >> 5700071

Sterol precursors of cholesterol in adult human brain.

G Galli, E G Paoletti, J F Weiss.   

Abstract

Adult human brain contains cholestanol and two series of cholesterol precursors having 30, 29, 28, and 27 carbon atoms; one has an unsaturated steroid nucleus, and the other is unsaturated in both nucleus and side chain. The ability of preparations of brain to incorporate a specific precursor into cholesterol, as well as into these sterol metabolites in vitro, indicates that cholesterol synthesis continues long after brain maturation ceases.

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Year:  1968        PMID: 5700071     DOI: 10.1126/science.162.3861.1495

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  4 in total

1.  Some pathways and mechanisms in lanosterol-cholesterol conversion in mammalian tissues.

Authors:  R Paoletti; G Galli; E Grossi Paoletti; A Fiecchi; A Scala
Journal:  Lipids       Date:  1971-02       Impact factor: 1.880

2.  The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods.

Authors:  R B Ramsey; J P Jones; S H Naqvi; H J Nicholas
Journal:  Lipids       Date:  1971-04       Impact factor: 1.880

3.  The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro.

Authors:  R B Ramsey; J P Jones; S H Naqvi; H J Nicholas
Journal:  Lipids       Date:  1971-03       Impact factor: 1.880

4.  Alzheimer's disease: brain desmosterol levels.

Authors:  Thomas Wisniewski; Kia Newman; Norman B Javitt
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

  4 in total

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