Literature DB >> 569688

Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels.

J M Barragry, H L Makin, D J Trafford, D F Scott.   

Abstract

Plasma sex hormone binding globulin (SHBG) and testosterone levels were measured in 29 patients with epilepsy (16 men and 13 women), most of them on chronic therapy with anticonvulsant drugs. Sex hormone binding globulin concentrations were increased in both sexes and testosterone levels in male patients. It is postulated that anticonvulsants may induce hepatic synthesis of SHBG.

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Year:  1978        PMID： 569688      PMCID： PMC493193          DOI： 10.1136/jnnp.41.10.913

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  3 in total

1.  A rapid method for the measurement of sex hormone binding globulin capacity of sera.

Authors:  B T Rudd; N M Duignan; D R London
Journal:  Clin Chim Acta       Date:  1974-09-16       Impact factor: 3.786

Review 2.  Sex-hormone-binding globulin.

Authors:  D C Anderson
Journal:  Clin Endocrinol (Oxf)       Date:  1974-01       Impact factor: 3.478

3.  Induction of sex hormone binding globulin by phenytoin.

Authors:  A Victor; P O Lundberg; E D Johansson
Journal:  Br Med J       Date:  1977-10-08
  3 in total
  7 in total

1.  Gynaecomastia induced by phenytoin in men with epilepsy.

Authors:  J P Monson; D F Scott
Journal:  Br Med J (Clin Res Ed)       Date:  1987-03-07

2.  Reduction of free testosterone by antiepileptic drugs.

Authors:  J Dana-Haeri; J Oxley; A Richens
Journal:  Br Med J (Clin Res Ed)       Date:  1982-01-09

3.  Endocrine function changes in young males during long-term antiepileptic therapy with phenobarbitone and carbamazepine.

Authors:  L Rozza; A Marcolla; G Ferrari
Journal:  Ital J Neurol Sci       Date:  1987-08

Review 4.  Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy.

Authors:  Jouko I T Isojärvi; Erik Taubøll; Andrew G Herzog
Journal:  CNS Drugs       Date:  2005       Impact factor: 5.749

Review 5.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

Review 6.  Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management.

Authors:  J Bauer; J I T Isojärvi; A G Herzog; M Reuber; D Polson; E Taubøll; P Genton; H van der Ven; B Roesing; G J Luef; C A Galimberti; J van Parys; D Flügel; A Bergmann; C E Elger
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-08       Impact factor: 10.154

7.  Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics.

Authors:  B K Toone; M Wheeler; M Nanjee; P Fenwick; R Grant
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-09       Impact factor: 10.154
  7 in total

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